In the development phase of optimised cell-based test systems, new active substances were identified and one of the identified peptides was also mechanistically characterised. The substances bring about increased sodium uptake and oedema resorption in the lungs. Drugs currently available for the treatment of pulmonary oedema have many negative side effects, especially in the case of patients with heart disease. In collaboration with industry partners, the extent to which the substances maintain the integrity of endothelial and epithelium monolayers was tested, as well as the extent to which they were suitable for treatments of diseases of the lungs and sepsis. Additionally, a method of rapidly and reproducibly distinguishing between metastasising and non-metastasising cancer cells was developed by means of the optimised use of ECIS and confocal laser scanning microscopy.
The project was funded by the FH Plus initiative under the COIN programme.