The purpose of this project is to investigate the pathophysiological role of the endosteal niche, and in particular the role of osteoblast precursors in the development of breast cancer bone metastases. The objectives of the research include identifying new biomarkers that predict the potential of tumour cells to form bone metastases. A further aim is to identify substances which prevent metastases by modifying the endosteal niche. Based on initial work using a 2D co-culture system, investigations will now also be conducted in a 3D system. The project is being carried out in close cooperation with Karl Landsteiner University of Health Sciences.
Biomarker-based therapeutic prevention of bone metastases in breast cancer: the pathophysiological role of the endosteal niche
Department of Life Sciences
- Further Information
- Status: Ongoing
- Project ID : 1134
- Project Leader
- Prof.(FH) Mag. Dr. Christoph WiesnerProfessor Department of Life Sciences