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Research institute for applied bioanalytics and drug development

Department of Life Sciences

Project Description

The pharmaceutical industry is currently outsourcing many areas of research to academic institutions. This trend has opened up new opportunities and fields of activity in translational and applied biomedical research and development. Collaboration with the industry will foster the establishment of sustainable scientific communication networks, databases, infrastructure and novel innovative technologies. The research institute therefore serves as an important incubator for emerging technologies at the Biotech-Area Krems in Lower Austria. The research institute focuses on identifying bioactive substances and biomolecules, their pharmaceutical optimization, and the preclinical and clinical monitoring of their therapeutic efficacy and adverse side effects. New drugs must meet safety requirements imposed by regulatory authorities such as the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA). All technologies and methods must meet the highest quality standards of Good Laboratory Practice (GLP), an internationally recognized quality assurance system for laboratory work. Research partners are the pharmaceutical industry, biotechnology companies (SMEs) and universities and research institutions.


Current projects and technologies are: (I.) Assessment of the immunogenicity of biomolecules (biologics),

Technologies: Enzyme linked immunosorbent assay (ELISA), electrochemiluminescence (ECL), Luminex multiplex assays (BioPlex 200 System), flow cytometry und FACS, cell-based assays (e.g. reporter assays, Fc-binding assay). (II.) Identification of therapeutic peptides and antibodies, Technologies: Phage-display, molecular modeling, bio-layer-interferometrie (Octet K2 system), cell-based Assays (e.g. drug dose-response relationship, in situ analyses, phenotype-based drug discovery). (III.) Development of complex organotypic disease models, Technologies: Tissue engineering, spheroid and organoids, tissue explants, precision-cut living tissue slices (PCTS)

  • Further Information
  • Status: Ongoing
  • Project ID : 453
  • Sponsor :

    Kein Fördergeber