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Our research projects at a glance

We carry out applied, interdisciplinary research in our core subjects: business, health and life sciences.

Take a look at our current research projects.

Projects

  • Department of Business
    business

    Hybrid parks – development of a measurement model

    This project, for Die Gärten Niederösterreichs (the gardens of Lower Austria association), is concerned with the economic, ecological and sociocultural impacts of parks and gardens (e.g. quality of life, image, qualitative regional effects) and will...

    This project, for Die Gärten Niederösterreichs (the gardens of Lower Austria association), is concerned with the economic, ecological and sociocultural impacts of parks and gardens (e.g. quality of life, image, qualitative regional effects) and will identify relevant indicators and measurement approaches to analyse these. In addition, proposals and recommendations for mutual (international) implementation will be developed. Based on the outcomes, a “toolbox” will be developed and recommendations derived.

  • Department of Business
    business

    Digital Competence Monitoring in Production Companies

    The NFB project on digital competence monitoring in manufactoring companies builds on research on competence development and aligns it to Industry 4.0. The approach of the researchers of the IMC University of Applied Sciences Krems, the University of...

    The NFB project on digital competence monitoring in manufactoring companies builds on research on competence development and aligns it to Industry 4.0. The approach of the researchers of the IMC University of Applied Sciences Krems, the University of Applied Sciences Wiener Neustadt and the Danube University Krems is based on Design-Based Research. In the research project practical experiences of production enterprises are collected and evaluated. Thus a competence model is developed, which is tested in enterprises and adapted on basis of these tests in several loops. This ensures continuous improvement and practical relevance of the model.

     

    The project is funded by Niederösterreichische Forschungs- und Bildungsges.m.b.H. (NFB).

  • Department of Life Sciences
    life-sciences

    Testing of recombinant polyclonal antibody fragments against gluten peptides

    Testing the recombinant avian polyclonal antibody fragments against gluten peptides that are produced and made available. These antibodies will be investigated using in vitro test systems (cell culture, intestinal epithelial cells) for their...

    Testing the recombinant avian polyclonal antibody fragments against gluten peptides that are produced and made available. These antibodies will be investigated using in vitro test systems (cell culture, intestinal epithelial cells) for their potential to inhibit inflammatory reactions in the intestinal epithelium caused by gluten peptides.

     

    The project was funded by the Austrian Research Promotion Agency under its basic programme.

  • Department of Life Sciences
    life-sciences

    RNA Interference as a method to inhibit virus infections

    Patients with an impaired immune system such as HIV-positive individuals or solid organ and particularly hematopoietic stem cell transplant recipients are at high risk of undergoing life-threatening infections with human adenoviruses. The efficacy of...

    Patients with an impaired immune system such as HIV-positive individuals or solid organ and particularly hematopoietic stem cell transplant recipients are at high risk of undergoing life-threatening infections with human adenoviruses. The efficacy of commonly used drugs to treat adenovirus infections is limited and frequently associated with toxicity. Alternative drugs are still under investigation. Hence, given the fact that numbers of solid organ and hematopoietic stem cell transplant recipients are constantly rising, alternative treatment options are highly needed.

     

    Short interfering RNAs (siRNAs) and artificial microRNAs (amiRNAs) are a class of artificial small RNAs that can bring about the inactivation of cellular and viral genes via the RNA interference (RNAi) pathway. In a previous project led by Dr. Reinhard Klein highly potent siRNAs and amiRNAs with activity against components of the adenoviral DNA replication machinery that can effectively inhibit the replication of human adenoviruses in cell culture experiments were developed and characterized.

     

    The project is aimed at investigating if adenovirus infections can be inhibited by these RNAi-triggering small RNAs in vivo, and which of the two approaches (i.e. siRNA versus amiRNA) is more effective. RNAi-based inhibition of adenoviruses is assessed in the Syrian hamster model which is able to mimic adenovirus infections in immunodeficient humans. Moreover, one of the two small RNA-based approaches is anticipated to lead to the selective amplification of the RNAi-triggering RNAs in adenovirus-infected cells and their transfer to neighbouring cells where they are supposed to inhibit the otherwise uncontrolled multiplication of spreading adenoviruses.

     

    The project is funded by the Austrian Science Fund (FWF).

  • Department of Business
    business

    Bottom-up energy transformation – socially innovative approaches and new actors

    One of the core questions related to achieving climate protection targets is how to bring “exhausted” potential for climate protection more closely into line with what is theoretically possible. Established policy instruments such as legislation,...

    One of the core questions related to achieving climate protection targets is how to bring “exhausted” potential for climate protection more closely into line with what is theoretically possible. Established policy instruments such as legislation, regulations, subsidies, information and advice do not appear to be sufficient. So what part could social innovations and bottom-up initiatives play in speeding up the Energiewende (“energy transformation”)? Who are the agents of social innovation in civil society and bottom-up processes? How can their plans be supported? This project is designed to examine these key questions.

     

    In this project, the project partners will assess energy- and climate protection-related social innovations and bottom-up processes, as well as potential key actors, and the findings will be appraised to determine their suitability for use in subsequent stages of the project. Action areas will be identified in which social innovations and bottom-up processes can play a part in bringing about the energy transformation. Ideas and approaches will then be developed and discussed in consultation with key actors from civil society as well as climate change and energy sector stakeholders. Recommendations will be drawn up on how actors involved in bottom-up processes and important agents of social innovation – with a focus on non-profit organisations and social enterprises – can be addressed and integrated into initiatives in future by the Austrian Climate and Energy Fund.

     

    The project is being funded by the Climate and Energy Fund.

  • Department of Business
    business

    Enterprise 4.0 – Success in the digital age

    The point of departure for this research project was the following question:

    In what specific ways can the digital revolution known as Industry 4.0, with its new technologies and forms of work, help manufacturing companies in the region to stay...

    The point of departure for this research project was the following question:

    In what specific ways can the digital revolution known as Industry 4.0, with its new technologies and forms of work, help manufacturing companies in the region to stay competitive and therefore maintain and create prosperity and jobs?

     

    Implementation applied the Enterprise 4.0 methodology, which analyses Industry 4.0 initiatives as follows:

    • Digital transformation: Which technologies were used and how? (incremental or disruptive innovation)

    • Internationalisation: What effect does the project have on the company’s global competitiveness? (return on sales, cost advantages, new business opportunities, effects on employment, site acquisition, ...)

    • Entrepreneurship: What business challenges need to be overcome?

    The members of E4.0 were all leading industrial firms that intensively discussed and worked together on Industry 4.0 topics (at management level and in detail at expert level) in a highly confidential setting. The project was highly focused on implementation and each company brought one of its major Industry 4.0/digital transformation projects to the table, in order to develop the topic with peers within the framework provided by the research project. Each of the companies was an industry leader in their sector, but none of them were direct competitors.

     

    The participating companies were NOVOMATIC AG, BENE GmbH, buntmetall amstetten Ges.m.b.H., Doka Österreich GmbH, Franz Haas Waffelmaschinen GmbH, Georg Fischer Fittings GmbH, HOERBIGER Kompressortechnik Holding GmbH, RIEGL Laser Measurement Systems GmbH, RIC (Regionales Innovations Centrum) GmbH, TEST-FUCHS GmbH and Welser Profile GmbH.

     

    The research partners were IMC University of Applied Sciences Krems, University of Applied Sciences Upper Austria, Vienna University of Economics and Business, TU Wien, St. Pölten University of Applied Sciences, and University of Applied Sciences Wiener Neustadt.

     

    Enterprise 4.0 was a project from the mechatronics and plastics cluster initiatives by ecoplus, the Lower Austrian business agency.

     

    Links to further information:

     

    Enterprise 4.0 project folder: www.ecoplus.at/media/4604/folder-projekt-enterprise-vier-punkt-null.pdf

  • Department of Business
    business

    Scan2VR

    The project aim is to capture environments, buildings, rooms, people and objects with the help of 3D scans and quickly implement them for a VR implementation, so that later these rooms can be "committed" with VR / AR / MR glasses.

    The Project ist...

    The project aim is to capture environments, buildings, rooms, people and objects with the help of 3D scans and quickly implement them for a VR implementation, so that later these rooms can be "committed" with VR / AR / MR glasses.

    The Project ist funded by the government of Lower Austria, Department Economy, Tourism and Technology.

  • Department of Life Sciences
    life-sciences

    In Vivo RNA interference strategies against adenoviruses

    Patients with an impaired immune system, such as HIV- positive patients and recipients of solid organ and particularly hematopoietic stem cell transplants, are at high risk of life-threatening infections with human adenoviruses. Among stem cell...

    Patients with an impaired immune system, such as HIV- positive patients and recipients of solid organ and particularly hematopoietic stem cell transplants, are at high risk of life-threatening infections with human adenoviruses. Among stem cell transplant recipients with systemic infections, mortality rates of almost 80% have been reported. The efficacy of commonly used drugs to treat adenovirus infections is limited and frequently associated with toxicity. Alternative drugs are still under investigation. In light of the fact that numbers of solid organ and hematopoietic stem cell transplant recipients are constantly rising, there is a pressing need for alternative treatment options.

     

    Short interfering RNAs (siRNAs) and artificial microRNAs (amiRNAs) are a class of artificial small RNAs that can bring about the inactivation of cellular and viral genes via the RNA interference (RNAi) pathway. In a previous project led by the investigators, highly potent siRNAs and amiRNAs with activity against components of the adenoviral DNA replication machinery that can effectively inhibit the replication of human adenoviruses in cell culture experiments were developed and characterised. The project is aimed at investigating if adenovirus infections can be inhibited by these RNAi-triggering small RNAs in vivo.

     

    The project is funded by the Austrian Science Fund (FWF).

  • Department of Business
    business

    The Wine Lab

    The Wine Lab knowledge alliance is aimed at establishing a structured university-business cooperation, by promoting active stakeholders dialogue and joint actions in order to generate innovative ideas for the sector growing, that can include either...

    The Wine Lab knowledge alliance is aimed at establishing a structured university-business cooperation, by promoting active stakeholders dialogue and joint actions in order to generate innovative ideas for the sector growing, that can include either new solutions for technical problems and particularly new approaches to the market (agribusiness, place branding, etc.); promote exchange and mutual learning between producers and researchers; identify learning gaps, both in students’ curricula and in lifelong learning for wine makers, in order to provide tailored learning offer; foster entrepreneurship mind-set of students in agriculture; establish local hubs of innovation, linked across Europe.

     

    The project is funded by the Erasmus+ Programme of the EU.

  • Department of Business
    business

    Innovations in family businesses: Contextual factors, processes and Performance effects

    In family businesses, innovation behaviour is often largely shaped by the idiosyncrasies of the business family. For instance, the business family’s desire to sustain the business over generations provides long-term capital (patient capital) to the...

    In family businesses, innovation behaviour is often largely shaped by the idiosyncrasies of the business family. For instance, the business family’s desire to sustain the business over generations provides long-term capital (patient capital) to the business and prompts family managers to make far-sighted investment decisions. Family businesses also often form part of strong and trusting social networks with stakeholders, creating many opportunities to mobilise people for new ideas.

    However, despite the fact that family businesses retain a number of assets that are conducive to innovation, investigations comparing the innovation output in family businesses and non-family businesses show ambiguous results. These results suggest that family businesses are both more and less innovative. These inconsistencies may be due to paradoxical effects of family involvement, as the family not only constitutes a resource but also a liability for innovation. For instance, family businesses prefer to avoid projects associated with high risk because they do not want to gamble with the inheritance of family members. They prefer continuity which prompts them to rely on what is tried-and- trusted and adhere to family traditions, instead of trying new things. Empirical evidence also indicates that the innovative capacity of family businesses frequently decreases across generations. Thus, although family businesses often have great innovation potential, they are sometimes reluctant to make use of this. This phenomenon is also known as the ability-willingness paradox.

     

    The question of how family businesses make use of their innovation capacity and why some family businesses are better innovators than others is therefore the focus of the current research project at the University of Applied Sciences Krems (in cooperation with the Research Institute for Family Businesses, Vienna University of Economics and Business).

     

    The project is co-financed by the Province of Lower Austria (Department K3 - Science and Research) and leading companies in the region.

  • Department of Health Sciences
    health-sciences

    The occupational balance project for informal caregivers (TOPIC)

    It is estimated that in one in four families in Austria there is someone caring for another family member or a friend or acquaintance. Informal caregiving can lead to changes in lifestyle and living environment, including organisational challenges...

    It is estimated that in one in four families in Austria there is someone caring for another family member or a friend or acquaintance. Informal caregiving can lead to changes in lifestyle and living environment, including organisational challenges and physical and psychological burdens, and necessitate adaptation of the caregiver’s daily routines to accommodate the needs of the dependant. These changes and adaptations can in turn impact the caregiver’s health and wellbeing. The monotony of activities can restrict a healthy variety of activities. In occupational therapy and occupational science this mix of different activities is referred to as occupational balance. Until now caregivers’ occupational balance has not been systematically investigated.

     

    The aim is to describe caregivers' occupational balance and other health-related factors and to explore possible associations between caregivers' occupational balance and health and wellbeing based on the analysis of reliable and valid measurements.

    Additionally, we aim to give students the opportunity to gain research experience, to contribute to connecting the areas of research, education and clinical practice and to strengthen the cooperation between the IMC University of Applied Sciences Krems, the respective university clinics and hospitals of the NÖ Landeskliniken-Holding and the Karl Landsteiner University of Health Sciences.

     

    The Project is funded by NÖGUS.

  • Department of Business
    business

    CaucaSusT - Transdisciplinarity for Sustainable Tourism Development in the Caucasus Region

    Science and research play an important role in the sustainable development of tourism worldwide. This role, as well as the link between science, practice and politics, are to be strengthened also in Armenia and Georgia by the CaucaSusT project. The...

    Science and research play an important role in the sustainable development of tourism worldwide. This role, as well as the link between science, practice and politics, are to be strengthened also in Armenia and Georgia by the CaucaSusT project. The project partners from Austria IMC UAS Krems and BOKU will share with local partners their expertise in the area of ​​sustainable tourism development as well as their experience in transdisciplinary research in order to create a suitable model for tourism research and teaching in these countries. Together with the Tbilisi State University and the Armenian State Pedagogical University, current problems of the sustainable tourism development in the pilot regions will be identified and integrated into the university courses through case studies and field research. These transdisciplinary research and teaching methods, will not only give students an insight into reality, but will also facilitate concrete solutions for the local tourism economy.

     

     

    The Academic Partnership between University of Natural Resources and Life Sciences, Vienna, (Lead Institution) IMC University of Applied Sciences Krems, Tbilisi State University and the Armenian State University will enable the project partners in Armenia and Georgia to address real problems of sustainable development - focusing on tourism development - in cooperation with the local population and other stakeholders. On a wider scale, the Academic Partnership will strengthen cooperation on academic activities on tourism development in the Caucasus region, and facilitate better coordination, coherence and integration of research outcomes into public policy in this field, via cooperating with and supporting activities of the regional Scientific Network for the Caucasus Mountain Region. The overall project goal is contribution to Capacity building for the universities in transdisciplinary teaching (case study teaching format, interdepartmental cooperation etc).

     

    The Project is funded by the Austrian Partnership Programme in Higher Education and Research for Development (APPEAR) under the fifth call, implemented by the Austrian Agency for International Cooperation in Education and Research (OeAD).

  • Department of Business
    business

    “GrünRaum”: Valorization of Green Spaces

    This project is examining the revitalisation of green spaces to exploit their tourism potential, as well as ways to enhance the quality of the visitor experience with respect to natural and cultural heritage (both tangible and intangible) in gardens...

    This project is examining the revitalisation of green spaces to exploit their tourism potential, as well as ways to enhance the quality of the visitor experience with respect to natural and cultural heritage (both tangible and intangible) in gardens and parks in Lower Austria and Southern Moravia. It is analysing the profiles and requirements of the various garden visitor segments. Based on these findings, a manual with quality criteria for the use of the managers of these green spaces will be developed. The project will also develop and present to the market new joint, cross-boarder garden tourism propositions.

     

    The project is funded by the EU’s INTERREG V-A Austria- Czech Republic programme.

     

    Website: http://diegaerten.eu/

  • Department of Business
    business

    Green spaces as a tourist attraction: Vienna in comparison to selected other European cities

    From a tourism sector point of view, green spaces in cities represent increasingly important leisure spaces, and are gaining significance alongside cultural attractions such as museums, events and distinct whole areas of a city. The aims of this...

    From a tourism sector point of view, green spaces in cities represent increasingly important leisure spaces, and are gaining significance alongside cultural attractions such as museums, events and distinct whole areas of a city. The aims of this project are to find out what role public parks and gardens play in city breaks, whether green spaces give a city a competitive advantage, and to gain insights into the needs of different visitors in terms of how they experience green spaces in a city.

     

    The project ist funded by the "Jubiläumsfonds" of the City of Vienna for the Vienna University of Economics and Business.

  • Department of Business
    business

    InRuTou - Innovation in Rural Tourism

    The InRuTou project aimed to address the challenges of rural mountain communities and to facilitate sustainable tourism in rural mountainous areas, by creating and testing a set of tools and innovative models and by training existing and new local...

    The InRuTou project aimed to address the challenges of rural mountain communities and to facilitate sustainable tourism in rural mountainous areas, by creating and testing a set of tools and innovative models and by training existing and new local tourism operators, which have various degrees of experience as well as different professional and educational backgrounds. The project brought together partners from universities, research institutes and regional development organisations from six countries (Austria, Great Britain, Italy, Romania, Poland, Ukraine) and its activities were implemented in six pilot areas located in five countries and across three different mountain ranges: the Alps, the Apennines and the Carpathians. More information on: www.inrutou.eu

     

    The project was funded under the EU-Programme Lifelong Learning Programme.

  • Department of Life Sciences
    life-sciences

    Viral and fungal infections

    The world-class standard of medical care in Austria means that many patients are now surviving in areas where previously treatments did not exist or were not widely available. This is thanks in no small part to developments in intensive care and...

    The world-class standard of medical care in Austria means that many patients are now surviving in areas where previously treatments did not exist or were not widely available. This is thanks in no small part to developments in intensive care and transplantation. But one consequence, in particular of the advances in transplantation, has been a steep rise in the number of immune-deficient patients with a considerably increased risk of otherwise harmless infectious diseases, such as infections with adenoviruses. These types of infections can prove fatal for people in this patient group. While bacterial infections can for the most part be effectively controlled using antibiotics, treatment options for viral infections are unsatisfactory, and the persistently high mortality rate is clear evidence of the need for action in this area. It is no longer the original illnesses that are responsible for the death of immune-deficient patients, but rather the infections described above. We must therefore accelerate development in this area and find ways to identify new drug targets.

     

     

    The aim of this research project is the systematic and scientific development of potential drug targets in the setting of infections in immune-deficient patients. The analysis of data obtained from in vitro models will afford new insights into the interplay between adenoviruses and human cells, which could lay the groundwork for further studies and the development of more effective therapies.

     

    The project is funded by the Austrian Research Promotion Agency under the sixth call for the “Aufbau” line of the COIN.

  • Department of Life Sciences
    life-sciences

    Development of new methods for improving oncological immunotherapy procedures

    For many cancer patients, conventional forms of chemotherapy are only partially successful due to their unspecific mode of action and their toxic side-effects. Innovative cell biological procedures involving the activation of tumour-specific T cells...

    For many cancer patients, conventional forms of chemotherapy are only partially successful due to their unspecific mode of action and their toxic side-effects. Innovative cell biological procedures involving the activation of tumour-specific T cells using dendritic cell therapy are possible alternatives. Dendritic cells are loaded or activated with tumour-associated antigens (RNA or proteins/peptides). The cells are then returned to the cancer patients in order to achieve in vivo a strong stimulation of tumour-specific cytotoxic and helper T cells, which attack and destroy the tumour. In a project conducted in collaboration with Life Research Technologies (LRT) GmbH, we have improved existing experimental strategies as well as developed new methods for the detection and quantification of the activity profiles of immune cells, in parallel with clinical studies.

  • Department of Life Sciences
    life-sciences

    Establishing innovative, vascular equivalents for the development of detection modules for high-throughput screening and for the development of anti-inflammatory peptides

    Peptides are isolated using phage display against TNF alpha and TNFR2, and then tested for anti-inflammatory properties in the planned vascular models. The vascular models should be suitable for high-throughput screening (HTS) and provide a basis for...

    Peptides are isolated using phage display against TNF alpha and TNFR2, and then tested for anti-inflammatory properties in the planned vascular models. The vascular models should be suitable for high-throughput screening (HTS) and provide a basis for the development of specialist detection modules by Beckman Coulter. Further tests on the isolated peptides were carried out by the industry partner. The data from the project will be used for the construction of prototype modules for the HTS market, and the peptides produced by the screening are expected to be further commercialised in follow-up projects.

     

    The project was funded by the Austrian Research Promotion Agency under the BRIDGE programme.

  • Department of Life Sciences
    life-sciences

    AdsorbTech: Development of a new techology platform for peptid-based therapeutic aphereses systems

    The aim of this project was the setup of a new technology platform in Lower Austria to make possible further developements and production of peptid-based adsorber in a quick, standardized and efficient way. Thus the aphereses could be established as...

    The aim of this project was the setup of a new technology platform in Lower Austria to make possible further developements and production of peptid-based adsorber in a quick, standardized and efficient way. Thus the aphereses could be established as an effective therapy against autoimmune disorders and sepsis in hospitals.

     

    The project was funded by the Austrian Research Promotion Agency under the call of the Bridge Programme line.

  • Department of Life Sciences
    life-sciences

    Development of innovative human tumour mimetics for the screening of bioactive agents

    Cancer-related morbidity and mortality represent a huge social and economic problem worldwide. Despite significant public and private investment in cancer research, there have still been no major advances in the treatment of most types of cancer....

    Cancer-related morbidity and mortality represent a huge social and economic problem worldwide. Despite significant public and private investment in cancer research, there have still been no major advances in the treatment of most types of cancer. Success in the selection of anti-carcinogenic substances (agents) using high-throughput screening (HTS) has been very modest, due to the limited physiological relevance of the cancer models and cellular assays used up to now.

     

    In this project, we developed innovative cell biological procedures which will help to create new generations of cancer models. A range of methods to generate three-dimensional (3D) cultures were developed. These 3D models included spheroids, heterotypic co-cultures and reporter cell lines. Using the models, it was possible to partially reconstruct the pathophysiological state of a tumour in vitro. In the course of several test series, it was shown that the standardized screening of agents was possible using the new 3D cell cultures.

     

    The project was funded by the Austrian Research Promotion Agency under the “Aufbau” funding line of the COIN – Cooperation and Innovation programme.

  • Department of Life Sciences
    life-sciences

    Synthesis and industrial application of hydroxytyrosol

    During the course of this project, an alternative synthesis of hydroxytyrosol will be developed. This new route aims for a higher yield of the important natural product by combining the advantages of biotechnological procedures and modern chemical...

    During the course of this project, an alternative synthesis of hydroxytyrosol will be developed. This new route aims for a higher yield of the important natural product by combining the advantages of biotechnological procedures and modern chemical reactions. Additionally, in collaboration with our industrial partner, a new and highly promising application of hydroxytyrosol in textile industry will be evaluated.

     

    Summarizing, the following goals can be defined:

    • Establish whole cell oxidation (dihydroxylation of aromatics) as innovative and future-oriented methodology at the University of Applied Sciences Krems. By means of this environmentally benign protocol, fine chemicals and pharmaceuticals are accessible from organic waste.

    • Synthesis of hydroxytyrosol, an important natural antioxidant with a wide range of applications in food industry, cosmetic industry, and pharmaceutical industry.

    • Evaluation of a newly developed analytical instrument to measure the metabolic activity of various bacteria.

    • Development of a new method for the mild and gentle selective bleaching of denim and related textiles.

     

     

    The project is co-financed by the Province of Lower Austria and the European Regional Development Fund (ERDF).

  • Department of Life Sciences
    life-sciences

    Biopharm - Isolation of bioactive compounds from cyanobacteria

    The pharmaceutical industry is increasingly focusing its attention on the wide variety of natural substances developed in the form of secondary metabolites in microorganisms. Marine algae in particular contain a significant, untapped resource in the...

    The pharmaceutical industry is increasingly focusing its attention on the wide variety of natural substances developed in the form of secondary metabolites in microorganisms. Marine algae in particular contain a significant, untapped resource in the shape of chemical structures with the potential to play a major part in the development of innovative medications.

     

    The project examined potential applications of constituents of blue-green algae in medical research on the treatment of chronic inflammations and cancer.

     

    The project involved purification of secondary metabolites from cyanobacteria using state-of-the-art chromatography processes and characterisation by means of mass spectrometry. The different fractions were then examined using human cell-culture models to identify their impact on inflammation processes and on cancer.

     

    The project was co-financed by the European Union through the European Regional Development Fund.

  • Department of Business
    business

    Scale(up) Alps - Accelerate and promote the Alpine Start-up Ecosystem

    The economy of the 21st century is affected by digitalization and accelerating innovation cycles. Start-ups seem to profit from the general economic development based globalization and digitalization. While Alpine Space can rely on growing and...

    The economy of the 21st century is affected by digitalization and accelerating innovation cycles. Start-ups seem to profit from the general economic development based globalization and digitalization. While Alpine Space can rely on growing and dynamic regional start-up ecosystems, many of these start-ups are facing obstacles when scaling up across Europe and beyond. The growing start-up communities are envisaged to link Alpine Space startup hubs, foster business acceleration, bridge SMEs-investors-policy-markets, involve actors in a community of opportunities. 11 European Partners (3x Italy, 3x France, 2x Slovenia, 1x Germany, 2x Austria) are working together in this EU funded project.

     

    SCALE(up)ALPS aims to make sure that the Alpine Space first, than EU Single Market, are the launch bases of alpine start-ups into the global competition. The main goals are, to connect innovation actors, increase knowledge transfer as well as to enhance Alpine Space key high-growth SMEs business innovation potential. The project will focus on defining a start-up integrated ecosystem growth-strategy as well as Alpine Space services to grow tech companies accessing new markets or disruptive businesses in existing markets.

     

    The Project ist funded by the Interreg Alpine Space Programme, a European transnational cooperation Programme for the Alpine region.

  • Department of Life Sciences
    life-sciences

    Functional validation of predictive biomarkers for targeted cancer therapies

    The genomic revolution has boosted the development of novel cancer therapeutics targeting critical oncogenic signaling molecules. The therapeutic agents often inactivate protein kinases resulting in growth arrest and death of cancer cells. However,...

    The genomic revolution has boosted the development of novel cancer therapeutics targeting critical oncogenic signaling molecules. The therapeutic agents often inactivate protein kinases resulting in growth arrest and death of cancer cells. However, clinical benefit is limited to subpopulations of cancer patients. Personalized cancer medicine seeks to identify the genetic factors (biomarkers) that influence drug sensitivity. The genetic characterization of tumors will be instrumental for the individualization of treatments and for successful patient outcome and minimization of drug toxicity.

     

    In the present project, we developed standardized diagnostic procedures that allow the detection of genetic biomarkers that can predict clinical drug response in cancer patients. The clinical relevance and the predictive value of the biomarkers have been partially validated in a retrospective clinical study focusing on breast cancer. The work required an interdisciplinary and multi-institutional collaboration between clinics, diagnostic centers and universities in Lower Austria, Tyrol, and Vienna. Genetic testing of cancer patients prior to therapy will increase the drug efficacy, safety, and cost-effectiveness of clinical treatments in cancer.

     

    The project was funded by the Niederösterreichische Forschungs- und Bildungsges.m.b.H. (NFB).

  • Department of Life Sciences
    life-sciences

    Cell-based test systems for bioactive substances

    In the development phase of optimised cell-based test systems, new active substances were identified and one of the identified peptides was also mechanistically characterised. The substances bring about increased sodium uptake and oedema resorption...

    In the development phase of optimised cell-based test systems, new active substances were identified and one of the identified peptides was also mechanistically characterised. The substances bring about increased sodium uptake and oedema resorption in the lungs. Drugs currently available for the treatment of pulmonary oedema have many negative side effects, especially in the case of patients with heart disease. In collaboration with industry partners, the extent to which the substances maintain the integrity of endothelial and epithelium monolayers was tested, as well as the extent to which they were suitable for treatments of diseases of the lungs and sepsis. Additionally, a method of rapidly and reproducibly distinguishing between metastasising and non-metastasising cancer cells was developed by means of the optimised use of ECIS and confocal laser scanning microscopy.

     

    The project was funded by the FH Plus initiative under the COIN programme.

  • Department of Business
    business

    Sustainable innovations in the hotel industry

    The debate on social and environmental challenges is slowly but steadily changing the sustainability understanding of a growing number of hoteliers, with the focus increasingly shifting to the perception of innovation opportunities, away from...

    The debate on social and environmental challenges is slowly but steadily changing the sustainability understanding of a growing number of hoteliers, with the focus increasingly shifting to the perception of innovation opportunities, away from sustainability as a tool for image enhancement. It is of particular importance that sustainability is perceived as an innovation opportunity, with the possibility of gaining a competitive advantage in order to stand out from the competition.

    Suggestions on the extent to which sustainable innovations can be implemented in the holiday and city hospitality sector are given in particular by four best practice examples, which were investigated by the IMC Fachochschule Krems.

     

    In all case studies, it is clear that corporate values ​​play a key role in sustainability and responsibility. The hotels have essential ideals and values ​​that they live with and which have often existed since the company's foundation or for several generations. They influence the assessment of new solutions and the future orientation of the activities of a hotel to a considerable extent.

     

    Sustainability is seen as an opportunity rather than a risk in our study. Developing solutions for societal challenges does not necessarily mean that this will lead to a cost increase for companies, but the use of innovative technologies, processes and management approaches can lead to increased productivity and an expansion of markets. Companies can discover a variety of opportunities to take on social responsibility, while at the same time expanding their competitive edge.

     

    The project is a result of the project "CSR and Innovation", funded by the COIN "Aufbau" (capacity building) funding line of the Austrian Research Promotion Agency.

  • Department of Business
    business

    Europe Engage - Developing a Culture of Civic Engagement through Service-Learning within Higher Education in Europe

    Europe Engage' seeks to embed the idea of the civic university through service-learning as a pedagogical approach within the participating universities, which enables students and universities to connect with society in order to maintain and develop...

    Europe Engage' seeks to embed the idea of the civic university through service-learning as a pedagogical approach within the participating universities, which enables students and universities to connect with society in order to maintain and develop democracy and healthy levels of social capital within the European context. Service-learning is a key approach in terms of incorporating a culture of civic and political literacy among the student population into higher education.

     

    The ‘Europe Engage’ Project seeks to embed the concept and practice of the civic university through Service-Learning (S-L) and student engagement with community. The overall aim of ‘Europe Engage’ will be to promote Service-Learning as a pedagogical approach that embeds and develops civic engagement within higher education, students, staff and the wider community.

     

    Europe Engage is a three-year project involving twelve institutions of higher education with experience and interest in this methodology.

     

    Link to project card:

    ec.europa.eu/programmes/erasmus-plus/projects/eplus-project-details/

     

    The project is funded by the Erasmus+ Programme of the EU.

  • Department of Life Sciences
    life-sciences

    The role of NRF2 in melanoma progression - insights into the mechanism of

    Melanoma is one of the most frequent tumours in young adults. Even though it only accounts for 4% of all cases of skin cancer, melanoma is responsible for 79% of all skin cancer-related deaths. Despite the progress that has been made in the treatment...

    Melanoma is one of the most frequent tumours in young adults. Even though it only accounts for 4% of all cases of skin cancer, melanoma is responsible for 79% of all skin cancer-related deaths. Despite the progress that has been made in the treatment of melanoma (e.g. with BRAF inhibitors), patients finally succumb due to resistance mechanisms acquired by the tumour. Many lines of evidence have shown that especially a metastatic melanoma exhibits a strong metabolic turnover, which is required to fuel cell proliferation and anabolic pathways. This increased cellular turnover also results in an increased demand to maintain the redox homeostasis. Here we propose analysing this high metabolic and therefore also ROS (reactive oxygen species) generating stress as a possible Achilles heel of melanoma. One of the major regulators of stress response in cancer is NRF2. It plays a central role in the protection of cells against oxidative and xenobiotic stresses.

     

    The inhibition of NRF2 or its target genes might re-establish the sensitivity of melanoma to apoptosis driven by ROS. This mechanism could also prevent resistance mechanisms frequently observed in metastatic melanoma and may eliminate the frequently observed activation of endothelial cells, which surround tumour cells. It is highly likely that a combination of state of the art melanoma treatment with compounds that inhibit the generation of ROS scavengers potentiates the effectiveness of the current treatment regiments. Here we will use CRISPR-based methods as well as pharmacological inhibition to elucidate the mechanistic role of NRF2 in melanoma cells and on endothelial cells. We will also Transfer knowledge gained from our model by closely cooperating with clinicians who routinely care for melanoma patients. We propose that eliminating the antioxidative response by suppressing NRF2 directly, or its targets, will be an effective weapon in the battle against metastatic melanoma.

     

    The project is funded by NÖ Forschungs- und Bildungsges.m.b.H (NFB).

  • Department of Business
    business

    dEUcert - Dissemination of European Certification Schema ECQA

    The dEUcert project promoted the European Certification and Quality Association (ECQA) and its Services. In the course of the project, a unified version of dissemination material was elaborated in English language and translated in 13 local languages...

    The dEUcert project promoted the European Certification and Quality Association (ECQA) and its Services. In the course of the project, a unified version of dissemination material was elaborated in English language and translated in 13 local languages for 60.000 individual persons. The partners focused their research activities on the interest of local markets about usage of ECQA services for existing and for new qualification schemes and developed a database for interested parties on local market and to integrate them at European level. On the basis of the research activities the ECQA portal was improved and the content was updated.

     

    The project was funded by the EU-Programm Lifelong Learning.

  • Department of Life Sciences
    life-sciences

    Extremophiles

    Extremophilic microorganisms often have special properties and also special metabolic pathways due to the cellular mechanisms necessary for their natural environment. These metabolic pathways include, among other things, the ability to use unusual...

    Extremophilic microorganisms often have special properties and also special metabolic pathways due to the cellular mechanisms necessary for their natural environment. These metabolic pathways include, among other things, the ability to use unusual carbon sources and to produce various end products therefrom. These products are of interest for many applications, including pharmaceutical applications. Products are for example various polyunsaturated fatty acids and also pigments. The cultivation of these organisms is possible with the equipment available at the IMC FH Krems and through international contacts to the TU Bratislava or the Sultan Quaboos University in Oman, there are possibilities to preserve the organisms or to use the methods of analysis and to bring them to Krems in the long term. Identified substances can then be tested for bioactivity using the cellular test systems developed in-house.

     

    The project is funded by the Province Lower Austria (Department Science and Research) under the technology fund programme ATHENOE.

  • Department of Business
    business

    EUCert. European Certificates Innovative Online Training Campus. Further development of an online learning platform system on the basis of the results of the EQN project. Lifelong Learning Programme.

    The objective of this project is to build on the established EU Certificates Association (www.eu-certificates.org, network for innovation in education, and pool of European professions applying the same quality and certification criteria in EU...

    The objective of this project is to build on the established EU Certificates Association (www.eu-certificates.org, network for innovation in education, and pool of European professions applying the same quality and certification criteria in EU countries based on the European Qualification framework, Aug 2005 – July 2007, Leonardo Network) and to integrate the results from a European research project which developed an integrated selective online learning platform system (EPI – Educational Partnership through ICT, 2003 – 2005, ) to build an online learning system for all the professions for training organisations from 14 European countries.

     

    The project was funded under the EU-Programme Lifelong Learning Programme.

  • Department of Life Sciences
    life-sciences

    DNA methylation in non-small call lung cancer and associated genderspecific influences on therapy efficience

    Lung cancer is characterised by genderspecific differences in carcinogenesis, prevalence

    and types of mutations as well as response to targeted therapies. The impact of a patient's

    gender on the tumor's DNA methylation pattern and on the efficiency...

    Lung cancer is characterised by genderspecific differences in carcinogenesis, prevalence

    and types of mutations as well as response to targeted therapies. The impact of a patient's

    gender on the tumor's DNA methylation pattern and on the efficiency of latest epigenetic

    therapies is still unknown and thus the research topic of this project.

     

    The Project is funded by FFG Talente - 4th Call FEMtech Research Projects.

  • Department of Business
    business

    Digital Business Transformation

    Digital transformation of companies and businesses goes beyond changes in the technological environment and application – it affects the very nature of a company. Surviving in a digitalised economy is an entrepreneurial challenge. There are new...

    Digital transformation of companies and businesses goes beyond changes in the technological environment and application – it affects the very nature of a company. Surviving in a digitalised economy is an entrepreneurial challenge. There are new business models and value chains, new industrial networks as well as new digital products. Digital technologies change business processes and top- down and bottom-up organisational structures. Digital transformation is an entrepreneurial challenge.

     

    The project aims to explore the success factors and conditions for the effective digital transformation of companies, and places a strong emphasis on the transformation from analogue to digital and digitalised business models.

     

    The research focuses on established companies, including international firms, in the process of digitalising their business models. It seeks to identify the most transformative developments in their industries and why and how they are responding to these.

     

    The project is co-financed by the Province of Lower Austria (Department K3 - Science and Research) and leading companies in the region.

  • Department of Life Sciences
    life-sciences

    Metabolic plasma profiling of the metabolic syndrome and cancer cachexia

    Abdominal obesity together with insulin resistance, dyslipidaemia and hypertension are hallmarks of the metabolic syndrome (MeS). Furthermore, this disease is also characterized by a low-grade-inflammatory status of adipose tissue causing changes in...

    Abdominal obesity together with insulin resistance, dyslipidaemia and hypertension are hallmarks of the metabolic syndrome (MeS). Furthermore, this disease is also characterized by a low-grade-inflammatory status of adipose tissue causing changes in lipid metabolism of adipocytes by misbalancing uptake, deposition and release of lipids and free fatty acids (FFAs). Markers for abnormal lipid metabolism and inflammation are also found to be elevated in patients suffering from cancer cachexia (CaC). We suppose that pathological alterations of the lipid metabolism are main contributors in MeS and CaC. Therefore, we hypothesize that metabolic signatures comprising lipid, eicosanoid and cytokine patterns are reflecting disease states and disease progression and can help to monitor the impact of clinical interventions. In this study, a comprehensive plasma profiling will be applied to characterize the lipid, eicosanoid and cytokine patterns of patients suffering from MeS and CaC. The goal of the project is to identify metabolic signatures indicative for the onset and progression of the diseases and for determining the therapeutic efficacy of clinical interventions. The Karl Landsteiner Private University of Health Sciences holds the lead of the project. Additional partners are the University of Vienna and Medical Universities of Vienna and Graz.

     

    The project was funded by the Niederösterreichische Forschungs- und Bildungsges.m.b.H. (NFB).

  • Department of Business
    business

    HEI-up: Improvement of Business Process Management in Higher Education institutions

    SMEs and Enterprises, which perform their activities on the market usually have their core business processes well managed. Identified, documented, standardized, managed, automatized business processes ensure they stay competitive on the market....

    SMEs and Enterprises, which perform their activities on the market usually have their core business processes well managed. Identified, documented, standardized, managed, automatized business processes ensure they stay competitive on the market. Nowadays, HEIs (higher education institutions) are faced with a shift from mass education, almost uniform age group (adolescents), employment status of students and finance sourcing to very different position. HEIs should adapt to study programme specialisation, broader target age group (lifelong learning), already employed students, which come from companies and various sources and combinations of financing (state, tuitions, projects, services, ...). Not only private HEIs, public HEIs are faced with mentioned changes also to improve HEI clients (=students, employees, partners) satisfaction and to remain competitive, HEI’s should manage their business processes similar to Enterprises and SMEs. Therefore, a business process management knowledge transfer should be initiated and maintained. Business Process Management (BPM) methodologies should be adapted to HEI specifics. Additionally, best practices of business processes from the enterprises and SMEs should be gathered, analyzed, modified and compiled into unified methodology for management of HEIs. Constant flow of BPM knowledge between HEIs and enterprises should also be maintained, to ensure exchange of field-based BPM experiences and theoretical knowledge.

     

    The Project was funded under the EU Programme Lifelong Learning Programme.

  • Department of Life Sciences
    life-sciences

    Research institute for applied bioanalytics and drug development

    The pharmaceutical industry is currently outsourcing many areas of research to academic institutions. This trend has opened up new opportunities and fields of activity in translational and applied biomedical research and development. Collaboration...

    The pharmaceutical industry is currently outsourcing many areas of research to academic institutions. This trend has opened up new opportunities and fields of activity in translational and applied biomedical research and development. Collaboration with the industry will foster the establishment of sustainable scientific communication networks, databases, infrastructure and novel innovative technologies. The research institute therefore serves as an important incubator for emerging technologies at the Biotech-Area Krems in Lower Austria. The research institute focuses on identifying bioactive substances and biomolecules, their pharmaceutical optimization, and the preclinical and clinical monitoring of their therapeutic efficacy and adverse side effects. New drugs must meet safety requirements imposed by regulatory authorities such as the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA). All technologies and methods must meet the highest quality standards of Good Laboratory Practice (GLP), an internationally recognized quality assurance system for laboratory work. Research partners are the pharmaceutical industry, biotechnology companies (SMEs) and universities and research institutions.

     

    Current projects and technologies are: (I.) Assessment of the immunogenicity of biomolecules (biologics),

    Technologies: Enzyme linked immunosorbent assay (ELISA), electrochemiluminescence (ECL), Luminex multiplex assays (BioPlex 200 System), flow cytometry und FACS, cell-based assays (e.g. reporter assays, Fc-binding assay). (II.) Identification of therapeutic peptides and antibodies, Technologies: Phage-display, molecular modeling, bio-layer-interferometrie (Octet K2 system), cell-based Assays (e.g. drug dose-response relationship, in situ analyses, phenotype-based drug discovery). (III.) Development of complex organotypic disease models, Technologies: Tissue engineering, spheroid and organoids, tissue explants, precision-cut living tissue slices (PCTS)

  • Department of Life Sciences
    life-sciences

    Co-cultivation of microorganisms

    Fermentation is an increasingly important area of the pharma- ceutical industry. Until now, academic research and industry have focused mainly on monocultures. However, it has been observed that many microorganisms only realise their full biochemical...

    Fermentation is an increasingly important area of the pharma- ceutical industry. Until now, academic research and industry have focused mainly on monocultures. However, it has been observed that many microorganisms only realise their full biochemical potential in tandem with others. As a result, co- cultivation has become a key pharmaceutical research Topic in the field of biotechnology.

     

    Research in this area concentrates on identifying potential co-cultures and establishing a fermentation process that harnesses the products and capabilities of microbial communities for drug discovery and industrial applications.

     

    The project represented an initial feasibility study of whether it is possible to identify conditions under which two selected microorganisms can grow separately from one another, and also of whether a stable co-culture can subsequently be established. The co-cultures were then analysed in terms of their ability to produce new substances.

     

    The project was funded by the Province of Lower Austria and the European Regional Development Fund (ERDF).

  • Department of Life Sciences
    life-sciences

    Development of complex extracorporeal carcinoma models for the identification of personalised Cancer therapies

    Intensive research into the molecular causes of cancer has led to the development of a range of innovative and targeted therapies which are used to selectively inactivate the molecular mechanisms responsible for tumour progression and the growth of...

    Intensive research into the molecular causes of cancer has led to the development of a range of innovative and targeted therapies which are used to selectively inactivate the molecular mechanisms responsible for tumour progression and the growth of cancer cells. These therapies can inhibit the proliferation of cancer cells and induce programmed cell death (apoptosis). They are not effective in all cancer patients due to the genetic heterogeneity of tumours. Personalised oncology aims to establish a direct link between tumour cell genotypes and sensitivity to bioactive substances, so that the patient first and foremost receives the targeted therapy with the maximum clinical benefit.

     

    In the project an experimental approach is being developed to complement diagnostic biomarker studies. We plan to develop organotypic cancer models that enable the direct testing of the clinical efficacy of cancer therapies in cell and tissue cultures (in vitro). A large number of potential cancer therapies, which are often combinations of targeted drugs and conventional chemotherapeutic agents, could

    be quickly tested for their clinical efficacy on a personalised Basis.

     

    The project is funded by Niederösterreichische Forschungs- und Bildungsges.m.b.H. (NFB).

  • Department of Life Sciences
    life-sciences

    Developing new immunoregulatory peptides and gender specific organotypic cell models for human sepsis

    Sepsis is one of the most frequent causes of death worldwide, including in Austria and Germany. Depending on the stage of the illness, between 25% and 60% of patients die despite receiving the maximum available treatment. In cases of sepsis, the...

    Sepsis is one of the most frequent causes of death worldwide, including in Austria and Germany. Depending on the stage of the illness, between 25% and 60% of patients die despite receiving the maximum available treatment. In cases of sepsis, the human immune system produces a hyperinflammatory response to an infection that has entered the blood stream, and this overreaction can lead to cardiovascular failure. This hyperinflammation is followed by immunosuppression – an attempt initiated by the immune system itself to counter this overreaction. Due to the reduced attentiveness of the immune system, many patients die from serious secondary infections during this phase. Owing to the complex progression of the disease, available sepsis therapies focus predominantly on tackling symptoms and are unfortunately ineffective in many cases.

     

    Peptides that modulate immune responses are currently regarded as promising new drug candidates for the treatment of sepsis. In this project, we aimed to develop and test new peptides that neutralise TRAIL/TNFSF10, one of the key immune regulators. Animal studies had suggested that inactivation of TRAIL/TNFSF10 is likely to reduce morbidity and mortality among patients suffering from sepsis. In addition, a gender- and cell-culture-based model for human sepsis was created, meaning that gender-specific differences (e. g. hormone status) could be taken into account when developing and validating potential new sepsis therapies.

     

    The project was funded by the Austrian Research Promotion Agency under the first call for FEMtech research projects

    in 2011.

  • Department of Life Sciences
    life-sciences

    Metastasising melanoma specific antibodies (MEMESA)

    Melanoma is the most aggressive form of skin cancer. If metastasis occurs, currently only about 10% of patients with the disease respond to standard treatment. This situation can be improved if patients at risk of metastasis are identified early, and...

    Melanoma is the most aggressive form of skin cancer. If metastasis occurs, currently only about 10% of patients with the disease respond to standard treatment. This situation can be improved if patients at risk of metastasis are identified early, and if patients in which metastasis has already occurred undergo targeted treatment. In this project we describe the generation of new types of antibodies that can identify metastasis-specific antigens in a targeted manner, and which are being tested for suitability for diagnosis. The strength of our approach lies in the combined use of completed preclinical studies, established cell culture methods and in vivo models, as well as the antibody production expertise of Sciotec Diagnostic Technologies GmbH.

     

    The Project under the consortial leadership of the Medical University of Vienna was funded by the Austrian Research Promotion Agency under the BRIDGE programme.

  • Department of Life Sciences
    life-sciences

    Establishing molecular toxicology for rapid, early and sensitive toxicity determination and biocompatibility

    The goal of the project is to combine a method comprising both cellular reporter assays and gene expression studies into a sensitive method. This would make it possible to show toxicological effects on human cells at significantly reduced...

    The goal of the project is to combine a method comprising both cellular reporter assays and gene expression studies into a sensitive method. This would make it possible to show toxicological effects on human cells at significantly reduced concentrations. If established successfully, the combined method could make a contribution to risk minimisation for newly developed biotech products and could also lead to an innovative screening procedure for the detection of toxic environmental pollutants not detectable using current analytical methods. The technology developed will be made available to biotech companies in Lower Austria in partnership projects.

     

    The project was financed by the Science and Research Department of the Province of Lower Austria.

  • Department of Life Sciences
    life-sciences

    Developing a design Pipeline for innovative protein-protein interaction inhibitors

    The functioning of living organisms is to a large extent dependent on the interplay between the biomolecules they are composed of. Protein-protein interactions (PPIs) are a basic mechanism that regulates this interplay. Consequently, in the past few...

    The functioning of living organisms is to a large extent dependent on the interplay between the biomolecules they are composed of. Protein-protein interactions (PPIs) are a basic mechanism that regulates this interplay. Consequently, in the past few years the search for active compounds that have a therapeutic influence on protein-protein interactions has been intensified. In most cases these compounds are inhibitors of these interactions.

     

    The aim of the project was to use a bacterial enzyme system in order to develop a prototypical workflow for the generation of hit structures for inhibition of protein-protein interactions (PPIs). Starting from the ACP/ACPS-system of Staphylococcus aureus peptides were identified that inhibit the ACP-ACPS-interaction. Peptide-ACP-interactions as well as ACPS-ACP-interactions were analyzed by NMR experiments. The insights obtained, together with structural information from available X-ray structures, led to the development of pharmacophore models that were used in virtual screening to identify potential small molecules PPI inhibitors.

     

    The project was funded by the Austrian Research Promotion Agency under the 15th call for the BRIDGE 1 programme line.

  • Department of Life Sciences
    life-sciences

    Engineering of therapeutic Peptides for cancer and regenerative medicine

    Proteins and peptides are key molecules in all biological processes. Their unique chemical properties make them particularly well suited for use as therapeutic agents. They have high biological activity and specificity with comparably few toxic side...

    Proteins and peptides are key molecules in all biological processes. Their unique chemical properties make them particularly well suited for use as therapeutic agents. They have high biological activity and specificity with comparably few toxic side effects, and can be used to produce a range of highly diversified compounds that are not subject to intellectual property restrictions. The market for synthetic therapeutic peptides is growing steadily, making it an increasingly attractive area for pharmaceutical companies.

     

    The research project’s specific focus was the development of peptides and antibodies that modulate the activity of receptor tyrosine kinases (RTKs, e.g. epidermal growth factor receptor (EGFR) and AXL). The work was performed in close cooperation with the Paracelsus Medical University Salzburg. In many cancers, the RTK signaling pathways are fundamental for proliferation, survival, angiogenesis and metastasis of cancer cells. Hence, inhibition of particular RTK pathways can induce apoptosis or senescence in the tumor cells. In addition, peptide or antibody mediated activation of RTKs could be beneficial for tissue engineering and regenerative medicine. This project has fostered the development of sustainable and cost-effective technologies for biopharmaceutical drug discovery, therapeutic apheresis, toxin neutralization and tissue engineering.

     

    The project was funded by the Niederösterreichische Forschungs- und Bildungsges.m.b.H. (NFB).

  • Department of Health Sciences
    health-sciences

    Horizons of personalised music therapy in neurorehabilitation

    The Josef Ressel Centre (JRC) takes a humanistic stance, approaching personalisation at a more communicative and psychophysiological level. As a consequence, the JRC carries out research into music therapy and not just into the effects of music....

    The Josef Ressel Centre (JRC) takes a humanistic stance, approaching personalisation at a more communicative and psychophysiological level. As a consequence, the JRC carries out research into music therapy and not just into the effects of music. Recognising that the “effects of (performing or listening to) music in the context of a therapeutic relationship” are very complex, the issue of personalisation of therapy is the JRC’s overriding research topic.

     

    The JRC’s new approach is geared towards personalisation and therefore combines research in the following two main Areas: Research on the psychophysiological disposition of the patient and the therapist and its influence on appropriate times of a therapy intervention for particular patients as well research on empathy-based therapeutic relationships in the light of selected psychophysiological correlates.

     

    The project is funded by Josef Ressel Centre Programme of the Christian Doppler Research Association, by NÖGUS and by s-team solutions GmbH.

  • Department of Health Sciences
    health-sciences

    Pilot Study: Measurement of empathy using the combination of psychometric and biometric procedures

    Ability for empathy applies in therapeutic work as essential factor of the relationship between patient and therapist and as crucial component during recovery. It is seen as a key factor in (musica-)therapeutic work to establish a confident,...

    Ability for empathy applies in therapeutic work as essential factor of the relationship between patient and therapist and as crucial component during recovery. It is seen as a key factor in (musica-)therapeutic work to establish a confident, therapeutic relationship between patient and therapist. Within this framework the therapist’s empathic care leads to a reduction of the opponent’s anxiety or rather stress reaction and enables a transformation into relaxation. In order to understand these processes it is necessary to explore empathy phenomenon. The focus of this project was the change of oxytocin-level in organisms in consequence of a empathic reaction caused by video sequences from clinic-therapeutic context.

     

    The Project was co-funded by the NÖGUS.

  • Department of Health Sciences
    health-sciences

    Positron Emission tomography (PET) and music therapy pilot study

    Brain injuries bring about a variety of physical and psychological complaints. The site and severity of the brain lesion is always a decisive factor for the patient’s outlook in terms of disability.

     

    Additionally, damage to the pathways between the...

    Brain injuries bring about a variety of physical and psychological complaints. The site and severity of the brain lesion is always a decisive factor for the patient’s outlook in terms of disability.

     

    Additionally, damage to the pathways between the brain centres can cause dysfunction in communication between them, and therefore secondary functional loss and processing problems. This results in neurological disorders such as poor concentration, attention and alertness.

     

    Music therapy can establish new communication paths in the brain and is therefore a promising form of therapy for rebuilding communication structures between brain centres. This process is of central importance in every course of neuro- rehabilitation therapy.

     

    The primary aim of the research was to determine the changes in brain activity (frontal lobe, hippocampus and cerebellum) and behaviour that can be brought about in vegetative state patients by means of music therapy. The project also examined if there are any links between changes in brain activity and behaviour.

     

    The project was co-financed by Niederösterreichischer Gesundheits- und Sozialfonds (NÖGUS).

  • Department of Health Sciences
    health-sciences

    The right moment - Pilot study on the representation of circadian and ultradian rhythms of patients in phase C neurorehabilitation by means of heart rate variability

    Over the last decade personalised medicine has become increasingly important in the fields of pharmacogenetics, pharmacogenomics, clinical diagnostics, and in particular chronopharmacology, which is concerned with the optimal point in time for drug...

    Over the last decade personalised medicine has become increasingly important in the fields of pharmacogenetics, pharmacogenomics, clinical diagnostics, and in particular chronopharmacology, which is concerned with the optimal point in time for drug delivery. However, with respect to therapeutic interventions (in a clinical context), there has been virtually no inquiry into the most beneficial time to give therapy in relation to a patient’s chronobiological rhythms. This project focused on the question of the ideal time to administer therapy in relation to individual biological rhythms, measured using heart rate variability (HRV).

     

    The primary aim was to establish how individual circadian and ultradian rhythms could be represented most effectively by means of HRV analysis.

     

    The project was financed by the Science and Research Department (K 3) of the Province of Lower Austria.

  • Department of Business
    business

    New world of work: performance measurement at Porsche Informatik GmbH

    As a key player in the digital transformation of the automotive sector, Porsche Informatik is remodelling itself as a next-generation company. Two core components of its transformation strategy are agile architecture and organisation, and adopting...

    As a key player in the digital transformation of the automotive sector, Porsche Informatik is remodelling itself as a next-generation company. Two core components of its transformation strategy are agile architecture and organisation, and adopting new approaches with a view to implementing new-world-of-work approaches.

     

    IMC Krems is providing academic support for the shift towards new, innovative working practices by means of performance assessment. Until 2020, the progress made by the organisation in the course of its transformation will be regularly evaluated, and areas in which optimisation and adjustments are required will be identified. To this end, the company’s productivity will be measured, as will the effectiveness of managerial approaches, which will be subject to fundamental changes as part of the transformation process. Overall, the performance assessment will equip employees and managers with a detailed “radar” for change – clear facts, figures and data will provide the basis for decision-making on the path towards establishing a next-generation business.

     

    The research project will also open up important links to the university’s teaching activities, in particular to the Digital Business Innovation and Transformation and International Export and Business Management master programmes, as well as the Collaboration in the Next Generation Enterprise specialist module, where students will have the opportunity to participate in the research project as part of their master thesis. The project will also be covered in major publications, such as the new edition of and supplementary chapters for Unternehmen der nächsten Generation, published by Springer. Regular updates will be posted on The New World of Work blog at www.newworldofwork.wordpress.com.

  • Department of Life Sciences
    life-sciences

    Sustainable biological recycling of environmentally hazardous substances (rare earth elements) from electronic waste and wastewater

    Rare earths are used in electronic devices such as mobile phones, computers and energy-saving bulbs. However, they are scarce and cannot be recycled using eco-friendly methods. Complex and expensive mining, coupled with scarce supply, means that the...

    Rare earths are used in electronic devices such as mobile phones, computers and energy-saving bulbs. However, they are scarce and cannot be recycled using eco-friendly methods. Complex and expensive mining, coupled with scarce supply, means that the prices of rare earths on the world market are rising steadily. Due to continuous technical advances, we can already predict that the supply situation for rare earths will become critical in future, which in turn could pose a threat to the development of innovative technologies.

     

    The project partners aim to counter this trend using a new technology. This involves an approach that has never been used before: recycling by means of microorganisms (bacteria and algae). The goal of the international project partner consortium is to develop a practicable recycling technology in collaboration with regional industry, with a view to reclaiming rare earths from electronic waste and subsequently making the technology available to businesses. The consortium liaises regularly with its strategic partners, which guarantees that market needs and the technological limitations of business are taken into account in the development process.

     

    The project is being funded as part of the EU’s INTERREG V-A Austria-Czech Republic programme.

  • Department of Business
    business

    Cultural (garden) heritage as a focal Point for sustainable Tourismus - CultTOUR

    Demand is growing for cultural tourism, a segment that stands out for its enormous variety of attractions on offer. However, very little research has been conducted in many areas of cultural tourism, including garden tourism. Parks, gardens and other...

    Demand is growing for cultural tourism, a segment that stands out for its enormous variety of attractions on offer. However, very little research has been conducted in many areas of cultural tourism, including garden tourism. Parks, gardens and other landscaped, green open spaces are now seen as important cultural attractions for tourist destinations, and are increasingly being developed to cater for tourists. Such locations also provide leisure opportunities for the local population, and can make a contribution to an area’s cultural identity and sustainable regional development.

     

    In the course of the three-year project, strategies and concepts were developed for preserving public and privately owned parks, gardens and other open spaces, and for their use in tourism. Feasibility studies were also conducted. A strategic management tool – the CultTour analysis tool – was developed to support parks and gardens managers in making their sites attractive to visitors and securing long-term income from tourism, while also taking account of environmental, economic and sociocultural sustainability.

     

    The project was funded by the South East Europe Transnational Cooperation Programme and co-funded by the European Regional Development Fund (ERDF) (2007-2013).

  • Department of Business
    business

    Local and Traditional Knowledge about Nature as Part of the Intangible Cultural Heritage - Safeguarding vs. Tourism Utilization

    Tourism development, based on traditional and local knowledge is important for highlighting the cultural features which distinguish one region from another. Knowledge and skills of local people, crafts, customs, rituals, festivals, etc. can be seen...

    Tourism development, based on traditional and local knowledge is important for highlighting the cultural features which distinguish one region from another. Knowledge and skills of local people, crafts, customs, rituals, festivals, etc. can be seen as cultural capital or as the intangible cultural heritage of local population . The intangible cultural heritage is difficult to "safeguard", is often not easy to stage for the visitors of a region, and can be made accessible and tangible through innovative leisure activities.

    In this research project, a concept for the simultaneous safeguarding, transfer and tourism valorization of traditional knowledge about nature will be created. Competences, practices and traditional knowledge of local people (e.g. about different crops, ecological gardening, medical plants etc.) are investigated in order to be made accessible to specific target groups and thus preserved. Experts and knowledge bearers, including older generations are identified and involved as informants. Scenarios for tourism development will be designed to ensure dialogue and knowledge transfer between regions, but also between generations. Furthermore, this tourism valorizatin can contribute to the safeguarding, promotion and development of intangible cultural heritage.

  • Department of Business
    business

    Corporate Social Responsibility (CSR) und Innovation Management

    CSR can play a major role in companies’ competitiveness. As a strategic and management approach, CSR can help businesses to exploit the opportunities for innovation presented by current and future social and environmental challenges. However, in...

    CSR can play a major role in companies’ competitiveness. As a strategic and management approach, CSR can help businesses to exploit the opportunities for innovation presented by current and future social and environmental challenges. However, in practice CSR activities are still rarely – or only to a limited degree – linked with innovation management.

     

    The project aimed to illustrate the effects of CSR on the various phases of the innovation cycle, and to develop suitable instruments and tools for SMEs and family businesses. This generated scientifically-based recommendations for ways in which SMEs and family businesses can optimise or implement innovation processes, on the basis of their CSR strategy and Goals.

     

    The project was funded by the Austrian Research Promotion Agency under the fourth call for the “Aufbau” line of the COIN – Cooperation & Innovation programme (programme owners/sponsors: Federal Ministry for Transport, Innovation and Technology; Federal Ministry of Science, Research and Economy).

  • Department of Business
    business

    Measuring Entrepreneurship Education Impact

    Can you teach and train entrepreneurship? Addressing this central question of Entrepreneurship Education Research was the goal of a research and evaluation project together with AWS Austria Wirtschaftsservice GmbH. By evaluating a one year program of...

    Can you teach and train entrepreneurship? Addressing this central question of Entrepreneurship Education Research was the goal of a research and evaluation project together with AWS Austria Wirtschaftsservice GmbH. By evaluating a one year program of entrepreneurship training (AWS First Program) and comparing it to the development of a controlgroup, we found significant training and learning effects regarding entrepreneurial know-how, as well as significant differences regarding entrepreneurial attitutes, motivation and attitude.

  • Department of Business
    business

    VR for SME

    The task was to develop innovative applications and solutions for SMEs and their environment with the help of students in different semesters and ideally different courses of study. These were used by the use of Virtual Reality (VR) to gain...

    The task was to develop innovative applications and solutions for SMEs and their environment with the help of students in different semesters and ideally different courses of study. These were used by the use of Virtual Reality (VR) to gain advantages in the context of their business operations in defined areas of application. For example: a better understanding among customers, acceptance of the company as an employer, aftercare in the medical-therapeutic area, virtual tour, virtual space, etc.

    The task was also to communicate in distributed teams and communicate interdisciplinarily and to improve the products / demos by means of different methods (Agile Programming, Open Innovation, Design thinking, ..). In addition to online communication with distributed teams, the students also learned how to communicate with customers and their visions regarding projects that affect your processes. In addition, a good insight into the world of VR / AR was achieved and the possibilities for the use of such technologies were mediated.

     

    The Project was funded by the Province of Lower Austria (Department K3 - Science and Research).

We celebrate the 25th anniversary of IMC Krems