Institute Biotechnology
Research, development and knowledge transfer are vibrant and dynamic aspects of the Institute of Biotechnology’s work.
We are involved in a steadily growing number of projects conducted in collaboration with research and industry partners from Austria and abroad. This collaborative approach also opens up new opportunities for our students, who are offered places on top-quality PhD programmes as a result of their participation in research partnerships with our institute.
Outstanding development opportunities
In order to maintain a strong research profile, the institute has identified three focus areas where it takes a highly interdisciplinary approach to research: medical biotechnology, bioprocess technology and materials science. The research groups within these focus areas provide excellent opportunities for young scientists to realise their potential.
Medical biotechnology
Our research into medical biotechnology focuses on identifying, validating and optimising molecules and biologics that can be used in personalised medicine or antiviral therapy, or as biomarkers. The institute has built up a wide range of methods and resources within this research focus over the past few years. The subjects we address include tissue engineering, creating human cell culture models, developing antiviral treatments, and optogenetic engineering of cell lines and receptors.
Bioprocess engineering
The bioprocess engineering research focus concentrates on systematic characterisation of bioreactors, optimisation of bioprocesses for manufacturing recombinant materials in bacterial host systems and yeast systems, and the establishment of co-cultivation of extremophile microorganisms to produce pharmaceutically effective secondary metabolites. The institute can also call on a host of innovative methods and resources in this field.
Materials science
Producing and characterising new materials, with an emphasis on renewable raw materials, is another key aspect of the institute’s work.
" In order to keep pace with the challenges currently facing society, we need to integrate innovative subjects and solutions derived from our research projects into teaching. This gives our graduates the skills they require to gain a foothold in high-tech sectors like the international pharmaceutical industry. "
Harald Hundsberger, Head of Institute Biotechnology
Team
Get to know the core team of our Institute Biotechnology.
Institute Biotechnology
Prof.(FH) Priv.-Doz. Mag. Dr. Harald Hundsberger
Head of Institute Biotechnology / Programme Director Medical and Pharmaceutical Biotechnology
Institute Biotechnology
- Recombinant Protein Expression, Cell Culture Models, Peptide Engineering,
- Instrument Development
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
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Immobilisierung von Kameloidantikörper für therapeutische Apherese und für die Unterstützung von Dialyse
Project Leader, Department of Science & Technology
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Extrazelluläre Vesikel aus dem Hoffa-Fettkörper - ein neuer Ansatz der Knorpelregeneration?
Department of Science & Technology
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Optogenetische Krebsmodelle
Project Leader, Department of Science & Technology
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Testung von rekombinanten polyklonalen Antikörperfragmenten gegen Gluten-Peptide
Project Leader, Department of Science & Technology
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Die Rolle von NFR2 in der Melanomprogression - Einblicke in die Mechanismen von Metastasen
Project Leader, Department of Science & Technology
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Etablierung der molekularen Toxikologie für rasche, frühzeitige sowie sensitive Toxizitätsbestimmungen und Biokompatibilität
Project Leader, Department of Science & Technology
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Entwicklung einer Design-Pipeline für innovative Protein-Protein-Interaktionshemmer
Department of Science & Technology
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MEMESA – Metastasierendes Melanom Spezifische Antikörper
Project Leader, Department of Science & Technology
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AdsorbTech: Entwicklung einer neuen Technologieplattform für Peptid-basierte therapeutische Apheresesysteme
Project Leader, Department of Science & Technology
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Entwicklung neuer immunregulierender Peptide und geschlechtsspezifischer organotypischer Zellmodelle für humane Sepsis
Department of Science & Technology
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Entwicklung neuer Methoden zur Verbesserung von immuntherapeutischen Verfahren in der Onkologie
Department of Science & Technology
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Funktionale Validierung prädiktiver Biomarker für zielgerichtete Krebstherapien
Department of Science & Technology
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Etablierung innovativer, vaskulärer Äquivalente zur Entwicklung von Detektionsmodulen für Hochdurchsatz-Verfahren und zur Entwicklung von anti-entzündlichen Peptiden
Project Leader, Department of Science & Technology
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Etablierung innovativer humaner Tumor-Mimetika für das Screening von bioaktiven Wirkstoffen
Department of Science & Technology
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Biopharm - Isolation bioaktiver Stoffe aus Cyanobakterien
Project Leader, Department of Science & Technology
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Zellbasierte Testsysteme für bioaktive Substanzen
Project Leader, Department of Science & Technology
Colleselli, K., Ebeyer-Masotta, M., Neuditschko, B., Stierschneider, A., Pollhammer, C., Potocnjak, M., Hundsberger, H., Herzog, F., Wiesner, C. (2023): Beyond Pattern Recognition: TLR2 Promotes Chemotaxis, Cell Adhesion, and Migration in THP-1 Cells. Cells, 12(10): 1425.
Doi: https://doi.org/10.3390/cells12101425Stierschneider, A., Neuditschko, B., Colleselli, K., Hundsberger, H., Herzog, F., & Wiesner, C. (2023): Comparative and Temporal Characterization of LPS and Blue-Light-Induced TLR4 Signal Transduction and Gene Expression in Optogenetically Manipulated Endothelial Cells. Cells, 12(697).
Doi: https://doi.org/10.3390/cells12050697Lucas, R., Hadizamani, Y., Enkhbaatar, P., Csanyi, G., Caldwell, R. W., Hundsberger, H., Sridhar, S., Lever, A. A., Hudel, M., Ash, D., Ushio-Fukai, M., Fukai, T., Chakraborty, T., Verin, A., Eaton, D. C., Romero, M., & Hamacher, J. (2022): Dichotomous Role of Tumor Necrosis Factor in Pulmonary Barrier Function and Alveolar Fluid Clearance. Frontiers in Physiology, 12: 793251.
Doi: https://doi.org/10.3389/fphys.2021.793251Weitzenböck, HP., Gschwendtner, A., Wiesner, C., Depke, M., Schmidt, F., Trautinger, F., Hengstschläger, M., Hundsberger, H., Mikula, M. (2022): Proteome analysis of NRF2 inhibition in melanoma reveals CD44 up-regulation and increased apoptosis resistance upon vemurafenib treatment. Cancer Medicine, 11(4): 956-967.
Doi: https://doi.org/10.1002/cam4.4506Stierschneider, A., Grünstäudl, P., Colleselli, K., Atzler, J., Klein, C., Hundsberger, H., Wiesner, C. (2021): Light-Inducible Spatio-Temporal Control of TLR4 and NF-κB-Gluc Reporter in Human Pancreatic Cell Line. International Journal of Molecular Sciences, 22(17): 9232.
Doi: https://doi.org/10.3390/ijms22179232Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717Kinslechner, K., Schütz, B., Pistek, M., Rapolter, P., Weitzenböck, H. P., Hundsberger, H., Mikulits, W., Grillari, J., Röhrl, C., Hengstschläger, M., Stangl, H., & Mikula, M. (2019): Loss of SR-BI Down-Regulates MITF and Suppresses Extracellular Vesicle Release in Human Melanoma. International journal of molecular sciences, 20(5): 1063.
Doi: https://doi.org/10.3390/ijms20051063Jacobi, N., Seeboeck, R., Hofmann, E., Schweiger, H., Smolinska, V., Mohr, T., Boyer, A., Sommergruber, W., Lechner, P., Pichler-Huebschmann, C., Önder, K., Hundsberger, H., Wiesner, C., & Eger, A. (2017): Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signaling. Oncotarget, 8(64): 107423–107440.
Doi: https://doi.org/10.18632/oncotarget.22475Hundsberger, H., Önder, K., Schuller-Götzburg, P., Virok, D. P., Herzog, J., & Rid, R. (2017): Assembly and use of high-density recombinant peptide chips for large-scale ligand screening is a practical alternative to synthetic peptide libraries. BMC genomics, 18(1): 450.
Doi: https://doi.org/10.1186/s12864-017-3814-3Jacobi, N., Smolinska, V., Seeboeck, R., Stierschneider, A., Klein, C., Hofmann, E., Wiesner, C., Mohr, T., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2017): 3D Anti-Cancer drug discovery models: A promising approach for precision medicine. In IMC Fachhochschule Krems GmbH (Hrsg.), Online-Tagungsband FHK Forschungsforum 2017. Krems: FFH.
Hundsberger, H., Koppensteiner, A., Hofmann, E., Ripper, D., Pflüger, M., Stadlmann, V., Klein, C. T., Kreiseder, B., Katzlinger, M., Eger, A., Forster, F., Missbichler, A., & Wiesner, C. (2017): A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells. SLAS discovery : advancing life sciences R & D, 22(8): 1035–1043.
Doi: https://doi.org/10.1177/2472555217697435Volk, K., Breunig, S. D., Rid, R., Herzog, J., Bräuer, M., Hundsberger, H., Klein, C., Müller, N., & Önder, K. (2017): Structural analysis and interaction studies of acyl-carrier protein (acpP) of Staphylococcus aureus, an extraordinarily thermally stable protein. Biological chemistry, 398(1): 125-133.
Doi: https://doi.org/10.1515/hsz-2016-0185Schütz, B., Koppensteiner, A., Schörghofer, D., Kinslechner, K., Timelthaler, G., Eferl, R., Hengstschläger, M., Missbichler, A., Hundsberger, H., & Mikula, M. (2016): Generation of metastatic melanoma specific antibodies by affinity purification. Scientific reports, 6: 37253.
Doi: https://doi.org/10.1038/srep37253Al-Harthy, T., Zoghaib, W. M., Pflüger, M., Schöpel, M., Önder, K., Reitsammer, M., Hundsberger, H., Stoll, R., & Abdel-Jalil, R. (2016): Design, Synthesis, and Cytotoxicity of 5-Fluoro-2-methyl-6-(4-aryl-piperazin-1-yl) Benzoxazoles. Molecules, 21(10): 1290.
Doi: https://doi.org/10.3390/molecules21101290Al-Harthy, T., Abdel-Jalil, R., Zoghaib, W., Pflüger, M., Hofmann, E., & Hundsberger, H. (2016): Design and synthesis of benzothiazole schiff bases of potential antitumor activity. Heterocycles, 92(7): 1282-1292.
Doi: https://doi.org/10.3987/COM-16-13471Hofmann, E., Seeboeck, R., Jacobi, N., Obrist, P., Huter, S., Klein, C., Oender, K., Wiesner, C., Hundsberger, H., & Eger, A. (2016): The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer. Biomarker research, 7(4): 8.
Doi: https://doi.org/10.1186/s40364-016-0062-7Jacobi, N., Smolinska, V., Stierschneider, A., Klein, C., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2016): Development of organotypic cancer models for the identification of individualized cancer therapies. In FH des BFI Wien (Hrsg.), Online-Tagungsband FHK Forschungsforum 2016. Wien: FFH.
Herzog, J., Rid, R., Wagner, M., Hundsberger, H., Eger, A., Bauer, J., & Önder, K. (2015): Whole-transcriptome gene expression profiling in an epidermolysis bullosa simplex Dowling-Meara model keratinocyte cell line uncovered novel, potential therapeutic targets and affected pathways. BMC research notes, 8: 785.
Doi: https://doi.org/10.1186/s13104-015-1783-7Kreiseder, B., Holper-Schichl, Y. M., Muellauer, B., Jacobi, N., Pretsch, A., Schmid, J. A., de Martin, R., Hundsberger, H., Eger, A., & Wiesner, C. (2015): Alpha-catulin contributes to drug-resistance of melanoma by activating NF-κB and AP-1. PloS one, 10(3): e0119402.
Doi: https://doi.org/10.1371/journal.pone.0119402Pretsch, A., Nagl, M., Schwendinger, K., Kreiseder, B., Wiederstein, M., Pretsch, D., Genov, M., Hollaus, R., Zinssmeister, D., Debbab, A., Hundsberger, H., Eger, A., Proksch, P., & Wiesner, C. (2014): Antimicrobial and anti-inflammatory activities of endophytic fungi Talaromyces wortmannii extracts against acne-inducing bacteria. PloS one, 9(6): e97929.
Doi: https://doi.org/10.1371/journal.pone.0097929Rid, R., Hundsberger, H., & Onder, K. (2014): Compound screening and transcriptional profiling in human primary keratinocytes: a brief guideline. Methods in molecular biology, 1195: 99-109.
Doi: https://doi.org/10.1007/7651_2013_50Kapuścik, A., Hrouzek, P., Kuzma, M., Bártová, S., Novák, P., Jokela, J., Pflüger, M., Eger, A., Hundsberger, H., Kopecký, J. (2013): Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent. Chembiochem : a European journal of chemical biology, 14(17): 2329-2337.
Doi: https://doi.org/10.1002/cbic.201300246Rid, R., Herzog, J., Maier, R. H., Hundsberger, H., Eger, A., Hintner, H., Bauer, J. W., Onder, K. (2013): Real-time monitoring of relative peptide-protein interaction strengths in the yeast two-hybrid system. Assay and drug development technologies, 11(4): 269-275.
Doi: https://doi.org/10.1089/adt.2012.496Rid, R., Wagner, M., Maier, C. J., Hundsberger, H., Hintner, H., Bauer, J. W., & Onder, K. (2013): Deciphering the calcitriol-induced transcriptomic response in keratinocytes: presentation of novel target genes. Journal of molecular endocrinology, 50(2): 131–149.
Doi: https://doi.org/10.1530/JME-11-0191Kreiseder, B., Orel, L., Bujnow, C., Buschek, S., Pflueger, M., Schuett, W., Hundsberger, H., de Martin, R., Wiesner, C. (2013): α‐Catulin downregulates E‐cadherin and promotes melanoma progression and invasion. International journal of cancer, 132(3): 521-530.
Doi: https://doi.org/10.1002/ijc.27698Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Onder, K., Kopecky, J., Schütt, W., Hundsberger, H. (2013): A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium. Journal of biomolecular screening, 18(1): 67-74.
Doi: https://doi.org/10.1177/1087057112458316Khare, V., Lyakhovich, A., Dammann, K., Lang, M., Borgmann, M., Tichy, B., Pospisilova, S., Luciani, G., Campregher, C., Evstatiev, R., Pflueger, M., Hundsberger, H., & Gasche, C. (2013): Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. Biochemical Pharmacology, 85(2): 234-244.
Doi: https://doi.org/10.1016/j.bcp.2012.10.026Maier, C., Maier, R., Rid, R., Trost, A., Hundsberger, H., Eger, A., Hintner, H., Bauer, J., Onder, K. (2012): PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling. BMC molecular biology, 13: 18.
Doi: https://doi.org/10.1186/1471-2199-13-18Amatschek, S., Lucas, R., Eger, A., Pflueger, M., Hundsberger, H., Knoll, C., Grosse-Kracht, S., Schuett, W., Koszik, F., Maurer, D., Wiesner, C. (2011): CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells. British journal of cancer, 104(3): 469-479.
Doi: https://doi.org/10.1038/sj.bjc.6606056Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D., Wendel, A., Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in Bioscience, 13: 5374-86.
Doi: https://doi.org/10.2741/3087Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D. N., Wendel, A., & Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in bioscience : a journal and virtual library, 13: 5374–5386.
Doi: https://doi.org/10.2741/3087Wiesner, C., Pflueger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schuett, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene interdisziplinar, 3(1).
Wiesner, C., Pflüger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schütt, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene Interdisziplinär, 3(1): Doc05.
Wiesner, C., Lucas, R., Pflueger, M., Kleber, C., Kopecky, J., Stys, D., Entler, B., Hundsberger, H., Atzler, J., Hrouzek, P., Lukesova, A., Schuett, W., (2007): Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites. Drug Metabolism Letters, 1(4): 254-260.
Doi: https://doi.org/10.2174/187231207783221385Lucas, R., Hundsberger, H., Pflueger, M., Fischer, B., Morel, D., Braun, C., Wendel, A., Chakraborty, T., Schuett, W., Wiesner, C., Hamacher, J. (2007): The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug. Letters in Drug Design & Discovery, 4(5): 336-340.
Doi: https://doi.org/10.2174%2F157018007780867816
Prof.(FH) Priv.-Doz. Mag. Dr. Harald HundsbergerHead of Institute Biotechnology / Programme Director Medical and Pharmaceutical BiotechnologyHead of Institute Biotechnology / Programme Director Medical and Pharmaceutical Biotechnology
Prof.(FH) Priv.-Doz. Mag. Dr. Harald Hundsberger
Core Competencies
- Recombinant Protein Expression, Cell Culture Models, Peptide Engineering,
- Instrument Development
Prof.(FH) Dr. Barbara Entler
Professor (FH) Institute Biotechnology
Institute Biotechnology
- Microbiology
- Microbial Monitoring
- Genetic Engineering
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
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EvoFerm
Department of Science & Technology
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Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Science & Technology
Moritz, B., Locatelli, V., Niess, M., Bathke, A., Kiessig, S., Entler, B., Finkler, C., Wegele, H., & Stracke, J. (2017): Optimization of capillary zone electrophoresis for charge heterogeneity testing of biopharmaceuticals using enhanced method development principles. Electrophoresis, 38(24): 3136–3146.
Doi: https://doi.org/10.1002/elps.201700145Wiesner, C., Pflueger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schuett, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene interdisziplinar, 3(1).
Wiesner, C., Pflüger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schütt, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene Interdisziplinär, 3(1): Doc05.
Wiesner, C., Lucas, R., Pflueger, M., Kleber, C., Kopecky, J., Stys, D., Entler, B., Hundsberger, H., Atzler, J., Hrouzek, P., Lukesova, A., Schuett, W., (2007): Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites. Drug Metabolism Letters, 1(4): 254-260.
Doi: https://doi.org/10.2174/187231207783221385
Prof.(FH) Dr. Barbara EntlerProfessor (FH) Institute BiotechnologyProf.(FH) DI Bernhard Klausgraber
Professor (FH) Institute Biotechnology
Institute Biotechnology
- Inorganic and Organic Chemistry
- Microbiology
- Fermentation Development and Optimization
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
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Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Science & Technology
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Synthese und industrielle Verwendung von Hydroxytyrosol
Department of Science & Technology
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Extremophiles
Project Leader, Department of Science & Technology
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Co-Kultivierung von Mikroorganismen
Department of Science & Technology
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Etablierung innovativer humaner Tumor-Mimetika für das Screening von bioaktiven Wirkstoffen
Department of Science & Technology
Prof.(FH) DI Bernhard KlausgraberProfessor (FH) Institute BiotechnologyProf.(FH) Dr. Christian Klein
Professor (FH) Institute Biotechnology
Institute Biotechnology
- Computer-Aided Drug Design
- Biochemical Systems Theory
- Molecular Modeling and Chemoinformatics
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
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EvoFerm
Department of Science & Technology
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Spike-Fermentation
Department of Science & Technology
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Entwicklung von therapeutischen Peptiden für Krebs- und regenerative Medizin
Department of Science & Technology
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Entwicklung einer Design-Pipeline für innovative Protein-Protein-Interaktionshemmer
Project Leader, Department of Science & Technology
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Entwicklung neuer immunregulierender Peptide und geschlechtsspezifischer organotypischer Zellmodelle für humane Sepsis
Department of Science & Technology
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Funktionale Validierung prädiktiver Biomarker für zielgerichtete Krebstherapien
Department of Science & Technology
Stierschneider, A., Grünstäudl, P., Colleselli, K., Atzler, J., Klein, C., Hundsberger, H., Wiesner, C. (2021): Light-Inducible Spatio-Temporal Control of TLR4 and NF-κB-Gluc Reporter in Human Pancreatic Cell Line. International Journal of Molecular Sciences, 22(17): 9232.
Doi: https://doi.org/10.3390/ijms22179232Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717Ablinger, C., Geisler, S. M., Stanika, R. I., Klein, C. T., & Obermair, G. J. (2020): Neuronal α2δ proteins and brain disorders. Pflugers Archiv : European journal of physiology, 472(7): 845-863.
Doi: https://doi.org/10.1007/s00424-020-02420-2Jacobi, N., Smolinska, V., Seeboeck, R., Stierschneider, A., Klein, C., Hofmann, E., Wiesner, C., Mohr, T., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2017): 3D Anti-Cancer drug discovery models: A promising approach for precision medicine. In IMC Fachhochschule Krems GmbH (Hrsg.), Online-Tagungsband FHK Forschungsforum 2017. Krems: FFH.
Hundsberger, H., Koppensteiner, A., Hofmann, E., Ripper, D., Pflüger, M., Stadlmann, V., Klein, C. T., Kreiseder, B., Katzlinger, M., Eger, A., Forster, F., Missbichler, A., & Wiesner, C. (2017): A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells. SLAS discovery : advancing life sciences R & D, 22(8): 1035–1043.
Doi: https://doi.org/10.1177/2472555217697435Volk, K., Breunig, S. D., Rid, R., Herzog, J., Bräuer, M., Hundsberger, H., Klein, C., Müller, N., & Önder, K. (2017): Structural analysis and interaction studies of acyl-carrier protein (acpP) of Staphylococcus aureus, an extraordinarily thermally stable protein. Biological chemistry, 398(1): 125-133.
Doi: https://doi.org/10.1515/hsz-2016-0185Hofmann, E., Seeboeck, R., Jacobi, N., Obrist, P., Huter, S., Klein, C., Oender, K., Wiesner, C., Hundsberger, H., & Eger, A. (2016): The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer. Biomarker research, 7(4): 8.
Doi: https://doi.org/10.1186/s40364-016-0062-7Jacobi, N., Smolinska, V., Stierschneider, A., Klein, C., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2016): Development of organotypic cancer models for the identification of individualized cancer therapies. In FH des BFI Wien (Hrsg.), Online-Tagungsband FHK Forschungsforum 2016. Wien: FFH.
Solca, F., Dahl, G., Zoephel, A., Bader, G., Sanderson, M., Klein, C.T., Kraemer, O., Himmelsbach, F., Haaksma, E., Adolf, G. R. (2012): Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker. Journal of Pharmacology and Experimental Therapeutics, 343(2): 342-350.
Doi: https://doi.org/10.1124/jpet.112.197756Klein, C.T., Kaiser, D., Ecker, G. (2004): 3D Topolgical Distance-Based Descriptors for Use in QSAR and Diversity Analysis. Journal of Chemical Information and Computer Sciences, 44(1): 200-209.
Doi: https://doi.org/10.1021/ci0256236Klein, C.T., Kaiser, D., Kopp, S., Chiba, P., Ecker, G. (2002): Similarity-Based SAR as Tool for Early ADME Profiling. Journal of Computer-Aided Molecular Design, 16: 785-793.
Doi: https://doi.org/10.1023/A:1023828527638Klein, C.T., Kaiblinger, N., Wolschann, P. (2002): Internally Defined Distances in 3D-Quantitative Structure-Activity Relationships. Journal of Computer-Aided Molecular Design, 16: 79-93.
Doi: https://doi.org/10.1023/A:1016308417830Mayer, B., Klein, C.T. (2000): Influence of Solvation on the Helix Forming Tendency of Nonpolar Amino Acids. Journal of Molecular Structure: THEOCHEM, 532(1-3): 213-226.
Doi: https://doi.org/10.1016/S0166-1280(00)00559-5Buchbauer, G., Klein, C.T., Wailzer, B., Wolschann, P. (2000): Threshold-Based Structure-Activity Relationships of Pyrazines with Bell Pepper Flavor. Journal of Agricultural and Food Chemistry, 48(9): 4273-4278.
Doi: https://doi.org/10.1021/jf000192hKlein, C.T., Polheim, D., Viernstein, H., Wolschann, P. (2000): A Method for Estimation of the Free Energies of Complexation between ß-Cyclodextrin and Guest Molecules. Journal of Inclusion Phenomena, 36(4): 409-423.
Doi: https://doi.org/10.1023/A:1008063412529Klein, C.T., Pircher, H., Wailzer, B., Buchbauer, G., Wolschann, P. (2000): Quantitative Structure-Property Study on Pyrazines with Bell Peper Flavor. Scientific Pharmaceutica, 68(1): 41-56.
Doi: https://doi.org/10.3797/scipharm.aut-00-04Klein, C.T., Lawtrakul, L., Hannongbua, S., Wolschann, P. (2000): Accessible Charges as Sensitive Descriptors in Structure-Activity Relationships. A Study on HEPT-based HIV-1 RT Inhibitors. Scientific Pharmaceutica, 68(1): 25-40.
Doi: https://doi.org/10.3797/scipharm.aut-00-03Klein, C.T., Viernstein, H., Wolschann, P. (2000): Free Energy Prediction of Complexation between ß-Cyclodextrin and Guest Molecules: External Predictivity of MR and PLS Models. Scientific Pharamaceutica, 68(1): 15-24.
Doi: https://doi.org/10.3797/scipharm.aut-00-02Klein, C.T., Polheim, D., Viernstein, H., Wolschann, P. (2000): Predicting the Free Energies of Complexation between Cyclodextrins and Guest Molecules: Linear versus Nonlinear Models. Pharamaceutical Research, 17: 358-365.
Doi: https://doi.org/10.1023/A:1007565409407Mayer, B., Klein, C.T., Köhler, G. (1999): Selective Assembly of Cyclodextrins on Poly(ethylene oxide) Poly(propylene oxide) Copolymers. Journal of Computer-Aided Molecular Design, 13: 373-383.
Doi: https://doi.org/10.1023/A:1008095501870Klein, C.T., Mayer, B. (1999): Sources for Switches and Structure Formation in Metabolic Pathways. Biosystems, 51(1): 41-52.
Doi: https://doi.org/10.1016/S0303-2647(99)00012-XKlein, C.T., Mayer, B., Köhler, G., Wolschann, P. (1998): Systematic Stepsize Variation: An Efficient Method for Searching the Conformational Space of Polypeptides. Journal of Computational Chemistry, 19(13): 1470-1481.
Doi: https://doi.org/10.1002/(SICI)1096-987X(199810)19:13<1470::AID-JCC4>3.0.CO;2-NKlein, C.T. (1998): Hysteresis-Driven Pattern Formation in Biochemical Networks. Journal of Theoretical Biology, 194(2): 263-274.
Doi: https://doi.org/10.1006/jtbi.1998.0757Mayer, B., Marconi, G., Klein, C.T., Köhler, G., Wolschann, P. (1997): Structural Analysis of Host–Guest Systems. Methyl-substituted Phenols in beta;-Cyclodextrin. Journal of inclusion phenomena and molecular recognition in chemistry, 29: 79-93.
Doi: https://doi.org/10.1023/A:1007920606983Klein, C.T., Mayer, B. (1997): A Model for Pattern Formation in Gap-Junction Coupled Cells. Journal of Theoretical Biology, 186(1): 107-115.
Doi: https://doi.org/10.1006/jtbi.1996.0337Grabner, G., Monti, S., Marconi, G., Mayer, B., Klein, C.T., Köhler, G. (1997): Spectroscopic and Photochemical Study of Inclusion Complexes of Dimethoxybenzenes with Cyclodextrins. The Journal of Physical Chemistry , 100(51): 20068-20075.
Doi: https://doi.org/10.1021/jp962231rMarconi, G., Mayer, B., Klein, C.T., Köhler, G. (1996): The structure of higher order C60-fullerene-γ-cyclodextrin complexes. Chemical Physics Letters, 260(5-6): 589-594.
Doi: https://doi.org/10.1016/0009-2614(96)00915-3Köhler, G., Grabner, G., Klein, C.T., Marconi, G., Mayer, B., Monti, S., Rechthaler, K., Rotkiewicz, K., Viernstein, H., Wolschann, P. (1996): Structure and spectroscopic Properties in Cyclodextrin Inclusion Complexes. In Szejtli, J., Szente, L. (Hrsg.), Proceedings of the Eighth International Symposium on Cyclodextrins (215-220). Budapest, Hungary: Springer, Dordrecht.
Doi: https://doi.org/10.1007/978-94-011-5448-2_46Klein, C.T., Mayer, B., Köhler, G., Wolschann, P. (1996): Influence of solvation on helix formation of poly-alanine studied by multiple annealing simulations. Journal of Molecular Structure: THEOCHEM, 372(1): 33-43.
Doi: https://doi.org/10.1016/S0166-1280(96)04745-8Klein, C. T., & Seelig, F. F. (1995): Turing structures in a system with regulated gap-junctions. Bio Systems, 35(1): 15–23.
Doi: https://doi.org/10.1016/0303-2647(94)01478-pKlein, C.T., Mayer, B., Köhler, G., Mraz, K., Reiter, S., Viernstein, H., Wolschann, P. (1995): Solubility and Molecular Modeling of Triflumizole-ß-cyclodextrin Inclusion Complexes. Journal of inclusion phenomena and molecular recognition in chemistry, 22: 15–32.
Doi: https://doi.org/10.1007/BF00706495
Prof.(FH) Dr. Christian KleinProfessor (FH) Institute BiotechnologyProf.(FH) Priv.Doz. Dr. Reinhard Klein
Professor (FH) Institute Biotechnology
Institute Biotechnology
- Virology
- Molecular biology
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
-
EvoFerm
Department of Science & Technology
-
In-Vivo-RNA Interferenzstrategien gegen Adenoviren
Project Leader, Department of Science & Technology
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Virale und fungale Infektionen
Project Leader, Department of Science & Technology
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RNA Interferenz als Methode zur Inhibierung von Virusinfektionen
Project Leader, Department of Science & Technology
Selb, R., Derntl, C., Klein, R., Alte, B., Hofbauer, C., Kaufmann, M., Beraha, J., Schöner, L., & Witte, A. (2017): The Viral Gene ORF79 Encodes a Repressor Regulating Induction of the Lytic Life Cycle in the Haloalkaliphilic Virus ϕCh1. Journal of virology, 91(9): e00206-17.
Doi: https://doi.org/10.1128/JVI.00206-17Derntl, C., Selb, R., Klein, R., Alte, B., & Witte, A. (2015): Genomic manipulations in alkaliphilic haloarchaea demonstrated by a gene disruption in Natrialba magadii. FEMS microbiology letters, 362(21): fnv179.
Doi: https://doi.org/10.1093/femsle/fnv179Derntl, C., Selb, R., Klein, R., Alte, B., & Witte, A. (2015): Genomic manipulations in alkaliphilic haloarchaea demonstrated by a gene disruption in Natrialba magadii. FEMS microbiology letters, 362(21): fnv179.
Doi: https://doi.org/10.1093/femsle/fnv179Bellutti, F., Kauer, M., Kneidinger, D., Lion, T., & Klein, R. (2015): Identification of RISC-associated adenoviral microRNAs, a subset of their direct targets, and global changes in the targetome upon lytic adenovirus 5 infection. Journal of virology, 89(3): 1608–1627.
Doi: https://doi.org/10.1128/JVI.02336-14Bellutti, F., Kauer, M., Kneidinger, D., Lion, T., & Klein, R. (2015): Identification of RISC-associated adenoviral microRNAs, a subset of their direct targets, and global changes in the targetome upon lytic adenovirus 5 infection. Journal of virology, 89(3): 1608–1627.
Doi: https://doi.org/10.1128/JVI.02336-14Ibrišimović, M., Lion, T., & Klein, R. (2013): Combinatorial targeting of 2 different steps in adenoviral DNA replication by herpes simplex virus thymidine kinase and artificial microRNA expression for the inhibition of virus multiplication in the presence of ganciclovir. BMC biotechnology, 13(1): 54.
Doi: https://doi.org/10.1186/1472-6750-13-54Mayrhofer-Iro, M., Ladurner, A., Meissner, C., Derntl, C., Reiter, M., Haider, F., Dimmel, K., Rössler, N., Klein, R., Baranyi, U., Scholz, H., & Witte, A. (2013): Utilization of virus φCh1 elements to establish a shuttle vector system for Halo(alkali)philic Archaea via transformation of Natrialba magadii. Applied and environmental microbiology, 79(8): 2741–2748.
Doi: https://doi.org/10.1128/AEM.03287-12Ibrišimović, M., Kneidinger, D., Lion, T., & Klein, R. (2013): An adenoviral vector-based expression and delivery system for the inhibition of wild-type adenovirus replication by artificial microRNAs. Antiviral research, 97(1): 10–23.
Doi: https://doi.org/10.1016/j.antiviral.2012.10.008Kneidinger, D., Ibrišimović, M., Lion, T., & Klein, R. (2012): Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery. Antiviral research, 94(3): 195–207.
Doi: https://doi.org/10.1016/j.antiviral.2012.03.011Ibrišimović, M., Nagl, U., Kneidinger, D., Rauch, M., Lion, T., & Klein, R. (2012): Targeted expression of herpes simplex virus thymidine kinase in adenovirus-infected cells reduces virus titers upon treatment with ganciclovir in vitro. The journal of gene medicine, 114(1): 3–19.
Doi: https://doi.org/10.1002/jgm.1638Klein, R., Rössler, N., Iro, M., Scholz, H., & Witte, A. (2012): Haloarchaeal myovirus φCh1 harbours a phase variation system for the production of protein variants with distinct cell surface adhesion specificities. Molecular microbiology, 83(1): 137–150.
Doi: https://doi.org/10.1111/j.1365-2958.2011.07921.xKlein, R., Ruttkowski, B., Schwab, S., Peterbauer, T., Salmons, B., Günzburg, W. H., & Hohenadl, C. (2008): Mouse mammary tumor virus promoter-containing retroviral promoter conversion vectors for gene-directed enzyme prodrug therapy are functional in vitro and in vivo. Journal of biomedicine & biotechnology, 2008(683505 ): 10.
Doi: https://doi.org/10.1155/2008/683505Agu, C. A., Klein, R., Lengler, J., Schilcher, F., Gregor, W., Peterbauer, T., Bläsi, U., Salmons, B., Günzburg, W. H., & Hohenadl, C. (2007): Bacteriophage-encoded toxins: the lambda-holin protein causes caspase-independent non-apoptotic cell death of eukaryotic cells. Cellular microbiology, 9(7): 1753–1765.
Doi: https://doi.org/10.1111/j.1462-5822.2007.00911.xIro, M., Klein, R., Gálos, B., Baranyi, U., Rössler, N., & Witte, A. (2007): The lysogenic region of virus phiCh1: identification of a repressor-operator system and determination of its activity in halophilic Archaea. xtremophiles : life under extreme conditions, 11(2): 383–396.
Doi: https://doi.org/10.1007/s00792-006-0040-3Klein, R., Ruttkowski, B., Knapp, E., Salmons, B., Günzburg, W. H., & Hohenadl, C. (2006): WPRE-mediated enhancement of gene expression is promoter and cell line specific. Gene, 372: 153–161.
Doi: https://doi.org/10.1016/j.gene.2005.12.018Hand, N. J., Klein, R., Laskewitz, A., & Pohlschröder, M. (2006): Archaeal and bacterial SecD and SecF homologs exhibit striking structural and functional conservation. Journal of bacteriology,, 188(4): 1251–1259.
Doi: https://doi.org/10.1128/JB.188.4.1251-1259.2006Agu, C. A., Klein, R., Schwab, S., König-Schuster, M., Kodajova, P., Ausserlechner, M., Binishofer, B., Bläsi, U., Salmons, B., Günzburg, W. H., & Hohenadl, C. (2006): The cytotoxic activity of the bacteriophage lambda-holin protein reduces tumour growth rates in mammary cancer cell xenograft models. The journal of gene medicine, 8(2): 229–241.
Doi: https://doi.org/10.1002/jgm.833Mangold, M., Siller, M., Roppenser, B., Vlaminckx, B. J., Penfound, T. A., Klein, R., Novak, R., Novick, R. P., & Charpentier, E. (2004): Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule. Molecular microbiology, 53(5): 1515–1527.
Doi: https://doi.org/10.1111/j.1365-2958.2004.04222.xRössler, N., Klein, R., Scholz, H., & Witte, A. (2004): Inversion within the genome of the haloalkaliphilic virus phiCh1 results in differential expression of structural proteins. Molecular microbiology, 52(2): 413–426.
Doi: https://doi.org/10.1111/j.1365-2958.2003.03983.xKlein, R., Baranyi, U., Rössler, N., Greineder, B., Scholz, H., & Witte, A. (2002): Natrialba magadii virus fCh: First complete nucleotide sequence and functional organization of a virus infecting an extreme haloalkaliphilic archaeon. Molecular microbiology, 45(3): 851–863.
Doi: https://doi.org/10.1046/j.1365-2958.2002.03064.xKlein, R., Greineder, B., Baranyi, U., & Witte, A. (2000): The structural protein E of the archaeal virus phiCh1: evidence for processing in Natrialba magadii during virus maturation. Virology, 276(2): 376–387.
Doi: https://doi.org/10.1006/viro.2000.0565Baranyi, U., Klein, R., Lubitz, W., Krüger, D. H., & Witte, A. (2000): The archaeal halophilic virus-encoded Dam-like methyltransferase M. phiCh1-I methylates adenine residues and complements dam mutants in the low salt environment of Escherichia coli. Molecular microbiology, 35(5): 1168–1179.
Doi: https://doi.org/10.1046/j.1365-2958.2000.01786.xKatinger, A., Lubitz, W., Szostak, M. P., Stadler, M., Klein, R., Indra, A., Huter, V., & Hensel, A. (1999): Pigs aerogenously immunized with genetically inactivated (ghosts) or irradiated Actinobacillus pleuropneumoniae are protected against a homologous aerosol challenge despite differing in pulmonary cellular and antibody responses. Journal of biotechnology, 73(2-3): 251–260.
Doi: https://doi.org/10.1016/s0168-1656(99)00143-1Witte, A., Baranyi, U., Klein, R., Sulzner, M., Luo, C., Wanner, G., Krüger, D. H., & Lubitz, W. (1997): Characterization of Natronobacterium magadii phage phi Ch1, a unique archaeal phage containing DNA and RNA. Molecular microbiology, 23(3): 603–616.
Doi: https://doi.org/10.1046/j.1365-2958.1997.d01-1879.xSzostak, M. P., Hensel, A., Eko, F. O., Klein, R., Auer, T., Mader, H., Haslberger, A., Bunka, S., Wanner, G., & Lubitz, W. (1996): Bacterial ghosts: non-living candidate vaccines. Journal of biotechnology, 44(1-3): 161–170.
Doi: https://doi.org/10.1016/0168-1656(95)00123-9
Prof.(FH) Priv.Doz. Dr. Reinhard KleinProfessor (FH) Institute BiotechnologyProf.(FH) Mag. Dana Mezricky
Professor (FH) Institute Biotechnology
Institute Biotechnology
- GMP/GLP
- Molecular Biology
- Proteinchemistry / Immunology/ Biochemical Analytics Methods
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
-
EvoFerm
Department of Science & Technology
-
Spike-Fermentation
Department of Science & Technology
-
Theraferm
Department of Science & Technology
-
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Science & Technology
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Extremophiles
Department of Science & Technology
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Co-Kultivierung von Mikroorganismen
Department of Science & Technology
Nahlik,V., Cizkova,M., Singh,A., Mezricky,D., Rucki,M., Andresen,E., Vitova,M. (2022): Growth of the Red Alga Galdieria suphuraria in Re Mud-Containing Medium and Accumulation of Rare Earth Elements. Springer Nature: Waste and Biomass Valorization , 13(12, Dezember 2022): -.
Doi: https://doi.org/10.1007/s12649-022-02021-3Náhlík, V., Zachleder, V., Čížková, M., Bišová, K., Singh, A., Mezricky, D., Řezanka, T., Vítová, M. (2021): Growth under Different Trophic Regimes and Synchronization of the Red Microalga Galdieria sulphuraria. Biomolecules, 11(7)(939).
Čížková, M., Mezricky, P., Mezricky, D., Rucki, M., Zachleder, V., Vítová, M. (2020): Bioaccumulation of Rare Earth Elements from Waste Luminophores in the Red Algae, Galdieria phlegrea. Waste Biomass Valor.
Doi: https://doi.org/10.1007/s12649-020-01182-3Rezanka, T., Rezanka, M., Mezricky, D., Vítova, M. (2020): Lipidomic analysis of diatoms cultivated with silica nanoparticles. Phytochemistry, 177: 112452.
Doi: https://doi.org/10.1016/j.phytochem.2020.112452Čížková, M., Mezricky, D., Rucki, M., Tóth, T. M., Náhlík, V., Lanta, V., Bišová, K., Zachleder, V., & Vítová, M. (2019): Bio-mining of Lanthanides from Red Mud by Green Microalgae. Molecules , 24(7): 1356.
Doi: https://doi.org/10.3390/molecules24071356Řezanka, T., Kaineder, K., Mezricky, D., Řezanka, M., Bišová, K., Zachleder, V., & Vítová, M. (2016): The effect of lanthanides on photosynthesis, growth, and chlorophyll profile of the green alga Desmodesmus quadricauda. Photosynthesis Research, 130(1-3): 335-346.
Doi: https://doi.org/10.1007/s11120-016-0263-9
Prof.(FH) Mag. Dana MezrickyProfessor (FH) Institute BiotechnologyDipl.Biol. Maren Pflüger, PhD
Scientist Institute Biotechnology
Institute Biotechnology
- Inflammation
- Cytotoxicity
- Wound healing
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
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Extremophiles
Department of Science & Technology
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Etablierung innovativer humaner Tumor-Mimetika für das Screening von bioaktiven Wirkstoffen
Department of Science & Technology
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Biopharm - Isolation bioaktiver Stoffe aus Cyanobakterien
Department of Science & Technology
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Zellbasierte Testsysteme für bioaktive Substanzen
Department of Science & Technology
Hundsberger, H., Koppensteiner, A., Hofmann, E., Ripper, D., Pflüger, M., Stadlmann, V., Klein, C. T., Kreiseder, B., Katzlinger, M., Eger, A., Forster, F., Missbichler, A., & Wiesner, C. (2017): A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells. SLAS discovery : advancing life sciences R & D, 22(8): 1035–1043.
Doi: https://doi.org/10.1177/2472555217697435Al-Harthy, T., Zoghaib, W. M., Pflüger, M., Schöpel, M., Önder, K., Reitsammer, M., Hundsberger, H., Stoll, R., & Abdel-Jalil, R. (2016): Design, Synthesis, and Cytotoxicity of 5-Fluoro-2-methyl-6-(4-aryl-piperazin-1-yl) Benzoxazoles. Molecules, 21(10): 1290.
Doi: https://doi.org/10.3390/molecules21101290Al-Harthy, T., Abdel-Jalil, R., Zoghaib, W., Pflüger, M., Hofmann, E., & Hundsberger, H. (2016): Design and synthesis of benzothiazole schiff bases of potential antitumor activity. Heterocycles, 92(7): 1282-1292.
Doi: https://doi.org/10.3987/COM-16-13471Kapuścik, A., Hrouzek, P., Kuzma, M., Bártová, S., Novák, P., Jokela, J., Pflüger, M., Eger, A., Hundsberger, H., Kopecký, J. (2013): Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent. Chembiochem : a European journal of chemical biology, 14(17): 2329-2337.
Doi: https://doi.org/10.1002/cbic.201300246Kreiseder, B., Orel, L., Bujnow, C., Buschek, S., Pflueger, M., Schuett, W., Hundsberger, H., de Martin, R., Wiesner, C. (2013): α‐Catulin downregulates E‐cadherin and promotes melanoma progression and invasion. International journal of cancer, 132(3): 521-530.
Doi: https://doi.org/10.1002/ijc.27698Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Onder, K., Kopecky, J., Schütt, W., Hundsberger, H. (2013): A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium. Journal of biomolecular screening, 18(1): 67-74.
Doi: https://doi.org/10.1177/1087057112458316Khare, V., Lyakhovich, A., Dammann, K., Lang, M., Borgmann, M., Tichy, B., Pospisilova, S., Luciani, G., Campregher, C., Evstatiev, R., Pflueger, M., Hundsberger, H., & Gasche, C. (2013): Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. Biochemical Pharmacology, 85(2): 234-244.
Doi: https://doi.org/10.1016/j.bcp.2012.10.026Amatschek, S., Lucas, R., Eger, A., Pflueger, M., Hundsberger, H., Knoll, C., Grosse-Kracht, S., Schuett, W., Koszik, F., Maurer, D., Wiesner, C. (2011): CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells. British journal of cancer, 104(3): 469-479.
Doi: https://doi.org/10.1038/sj.bjc.6606056Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D., Wendel, A., Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in Bioscience, 13: 5374-86.
Doi: https://doi.org/10.2741/3087Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D. N., Wendel, A., & Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in bioscience : a journal and virtual library, 13: 5374–5386.
Doi: https://doi.org/10.2741/3087Wiesner, C., Pflueger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schuett, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene interdisziplinar, 3(1).
Wiesner, C., Pflüger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schütt, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene Interdisziplinär, 3(1): Doc05.
Wiesner, C., Lucas, R., Pflueger, M., Kleber, C., Kopecky, J., Stys, D., Entler, B., Hundsberger, H., Atzler, J., Hrouzek, P., Lukesova, A., Schuett, W., (2007): Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites. Drug Metabolism Letters, 1(4): 254-260.
Doi: https://doi.org/10.2174/187231207783221385Lucas, R., Hundsberger, H., Pflueger, M., Fischer, B., Morel, D., Braun, C., Wendel, A., Chakraborty, T., Schuett, W., Wiesner, C., Hamacher, J. (2007): The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug. Letters in Drug Design & Discovery, 4(5): 336-340.
Doi: https://doi.org/10.2174%2F157018007780867816
Dipl.Biol. Maren Pflüger, PhDScientist Institute BiotechnologyWadih Rassy, MSc
Scientist Institute Biotechnology
Institute Biotechnology
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
-
EvoFerm
Department of Science & Technology
-
Theraferm
Department of Science & Technology
-
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Science & Technology
-
Synthese und industrielle Verwendung von Hydroxytyrosol
Department of Science & Technology
Rassy, W., Ripper, D., Pomare, E., Winkler, S., Koppensteiner, A., Spadiut O.,Schild, D. (2023): Incorporation of ionic rare earth elements as a form of microbial environmental remediation. Frontiers in Environmental Science, 11(Section Toxicology, Pollution and the Environment).
Doi: https://doi.org/10.3389/fenvs.2023.1112612
Wadih Rassy, MScScientist Institute BiotechnologyDI(FH) Thomas Rieß
Scientific Project Staff Institute Biotechnology
Institute Biotechnology
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
-
EvoFerm
Department of Science & Technology
DI(FH) Thomas RießScientific Project Staff Institute BiotechnologyProf.(FH) DI Dominik Schild
Professor (FH) Institute Biotechnology
Institute Biotechnology
- Fermentation development
- Biochemical Engineering
- Process engineering
- Applied ChemistryBachelor of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
-
EvoFerm
Project Leader, Department of Science & Technology
-
Spike-Fermentation
Project Leader, Department of Science & Technology
-
Anwendung von Hydroxytyrosol zur Stabilisierung
Department of Science & Technology
-
Theraferm
Project Leader, Department of Science & Technology
-
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Project Leader, Department of Science & Technology
-
Synthese und industrielle Verwendung von Hydroxytyrosol
Project Leader, Department of Science & Technology
-
Extremophiles
Department of Science & Technology
-
Co-Kultivierung von Mikroorganismen
Project Leader, Department of Science & Technology
-
Zellbasierte Testsysteme für bioaktive Substanzen
Department of Science & Technology
Rassy, W., Ripper, D., Pomare, E., Winkler, S., Koppensteiner, A., Spadiut O.,Schild, D. (2023): Incorporation of ionic rare earth elements as a form of microbial environmental remediation. Frontiers in Environmental Science, 11(Section Toxicology, Pollution and the Environment).
Doi: https://doi.org/10.3389/fenvs.2023.1112612Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717Amer, H., Mimini, V., Schild, D., Rinner, U., Bacher, H., Potthast, A., Rosenau, T. (2019): Gram-scale economical synthesis of trans-coniferyl alcohol and its corresponding thiol. Holzforschung, 74(2): 197-202.
Doi: https://doi.org/10.1515/hf-2018-0297
Prof.(FH) DI Dominik SchildProfessor (FH) Institute BiotechnologyHon.-Prof.(FH) DI (FH) Rita Seeböck, PhD
Scientific Projekt Staff Institute Biotechnology
Institute Biotechnology
- Molecular Pathology
- Molecular Biology
- Diagnostics
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
-
Testung von rekombinanten polyklonalen Antikörperfragmenten gegen Gluten-Peptide
Department of Science & Technology
-
DNA Methylierung im Lungenkrebs und ihre geschlechtsspezifische
Auswirkung auf die Effizienz epigenetischer Therapien
Project Leader, Department of Science & Technology
Seeboeck, R., Sarne, V., & Haybaeck, J. (2019): Current Coverage of the mTOR Pathway by Next-Generation Sequencing Oncology Panels. International journal of molecular sciences, 20(3): 690.
Doi: https://doi.org/10.3390/ijms20030690Sarne, V., Braunmueller, S., Rakob, L., Seeboeck, R. (2019): The Relevance of Gender in Tumor-Influencing Epigenetic Traits. Epigenomes 2019, 3(1), 6.
Jacobi, N., Seeboeck, R., Hofmann, E., Schweiger, H., Smolinska, V., Mohr, T., Boyer, A., Sommergruber, W., Lechner, P., Pichler-Huebschmann, C., Önder, K., Hundsberger, H., Wiesner, C., & Eger, A. (2017): Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signaling. Oncotarget, 8(64): 107423–107440.
Doi: https://doi.org/10.18632/oncotarget.22475Rita Seeböck and Johannes Haybaeck (2017): Molecular Carcinogenesis of Urinary Bladder Cancer. In Mechanisms of Molecular Carcinogenesis Volume 2 (p.191-206). Cham, Switzerland: Springer.
Jacobi, N., Smolinska, V., Seeboeck, R., Stierschneider, A., Klein, C., Hofmann, E., Wiesner, C., Mohr, T., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2017): 3D Anti-Cancer drug discovery models: A promising approach for precision medicine. In IMC Fachhochschule Krems GmbH (Hrsg.), Online-Tagungsband FHK Forschungsforum 2017. Krems: FFH.
Jacobi, N., Seeboeck, R., Hofmann, E., & Eger, A. (2017): ErbB Family Signalling: A Paradigm for Oncogene Addiction and Personalized Oncology. Cancers, 9(4): 33.
Doi: https://doi.org/10.3390/cancers9040033Hofmann, E., Seeboeck, R., Jacobi, N., Obrist, P., Huter, S., Klein, C., Oender, K., Wiesner, C., Hundsberger, H., & Eger, A. (2016): The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer. Biomarker research, 7(4): 8.
Doi: https://doi.org/10.1186/s40364-016-0062-7Zopf A, Raim R, Danzer M, Niklas N, Spilka R, Pröll J, Gabriel C, Nechansky A, Roucka M. (2015): Introduction of the hybcell-based compact sequencing technology and comparison to state-of-the-art methodologies for KRAS mutation detection. Biotechniques 58(3):126-34.
Spilka, R., Ernst, C., Bergler, H., Rainer, J., Flechsig, S., Vogetseder, A., Lederer, E., Benesch, M., Brunner, A., Geley, S., Eger, A., Bachmann, F., Doppler, W., Obrist, P., & Haybaeck, J. (2014): eIF3a is over-expressed in urinary bladder cancer and influences its phenotype independent of translation initiation. Cellular oncology (Dordrecht), 37(4): 253–267.
Doi: https://doi.org/10.1007/s13402-014-0181-9Tymoszuk P, Charoentong P, Hackl H, Spilka R, Müller-Holzner E, Trajanoski Z, Obrist P, Revillion F, Peyrat JP, Fiegl H, Doppler W (2014): High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer. BMC Cancer.
Spilka R, Ernst C, Mehta AK, Haybaeck J (2013): Eukaryotic translation initiation factors in cancer development and progression. REVIEW. Cancer Lett 340(1):9-21.
Pilat U, Dechat T, Bertrand AT, Woisetschläger N, Gotic I, Spilka R, Biadasiewicz K, Bonne G, Foisner R (2013): The muscle dystrophy-causing ΔK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2α complex in mice. J Cell Sci. 126(Pt 8):1753-62.
Seeböck R, Laimer K, Bachmann F, Spizzo G, Vogetseder A, Wieser M, Müller H, Haybaeck J, Obrist P (2012): Overexpression of eIF3a in Squamous Cell Carcinoma of the Oral Cavity and Its Putative Relation to Chemotherapy Response. J Oncol. 2012:901956.
Haybaeck J, O'Connor T, Seeböck R, Spizzo G, Ensinger Ch, Mikuz G, Brunhuber T, Vogetseder A, Theurl I, Salvenmoser W, Draxl H, Bänziger R, Bachmann F, Schäfer G, Burger M, Obrist P (2010): Overexpression of p150, a part of the large subunit of the eukaryotic translation initiation factor 3, in colon cancer. Anticancer Res. 30(4):1047-55..
Gotic I, Schmidt WM, Biadasiewicz K, Leschnik M, Spilka R, Braun J, Stewart CL, Foisner R (2010): Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination. Stem Cells 28(3):480-8.
Hon.-Prof.(FH) DI (FH) Rita Seeböck, PhDScientific Projekt Staff Institute BiotechnologyAnna Stierschneider, PhD
PhD Student Institute Biotechnology
Institute Biotechnology
-
Optogenetische Stammzellen in heterotypische Tumorsphäroiden
Department of Science & Technology
-
Entwicklung einer optogenetisch kontrollierbaren MSC-Zelllinie für die präzise Regulation immunmodulatorischer Faktoren
Department of Science & Technology
-
Entwicklung leistungsfähiger Diagnostikverfahren und neuer Therapieansätze in Inflammation und Sepsis
Department of Science & Technology
-
Theraferm
Department of Science & Technology
-
Optogenetische Krebsmodelle
Department of Science & Technology
Stierschneider, A., Wiesner, C. (2024): Shedding light on the molecular and regulatory mechanisms of TLR4 signaling in endothelial cells under physiological and inflamed conditions. Frontiers in Immunology, 14(1264889): 1-15.
Doi: https://doi.org/10.3389/fimmu.2023.1264889Colleselli, K., Stierschneider, A., Wiesner, C. (2023): An Update on Toll-like Receptor 2, Its Function and Dimerization in Pro- and Anti-Inflammatory Processes. International Journal of Molecular Sciences.
Doi: https://doi.org/10.3390/ijms241512464Colleselli, K., Ebeyer-Masotta, M., Neuditschko, B., Stierschneider, A., Pollhammer, C., Potocnjak, M., Hundsberger, H., Herzog, F., Wiesner, C. (2023): Beyond Pattern Recognition: TLR2 Promotes Chemotaxis, Cell Adhesion, and Migration in THP-1 Cells. Cells, 12(10): 1425.
Doi: https://doi.org/10.3390/cells12101425Stierschneider, A., Neuditschko, B., Colleselli, K., Hundsberger, H., Herzog, F., & Wiesner, C. (2023): Comparative and Temporal Characterization of LPS and Blue-Light-Induced TLR4 Signal Transduction and Gene Expression in Optogenetically Manipulated Endothelial Cells. Cells, 12(697).
Doi: https://doi.org/10.3390/cells12050697Woess, K.; Sun, Y.; Morio, H.; Stierschneider, A.; Kaufmann, A.; Hainzl, S.; Trattner, L.; Kocher, T.; Tockner, B.; Leb-Reichl, V.; Steiner, M.; Brachtl, G.; South, A.P.; Bauer, J.W.; Reichelt, J.; Furihata, T.; Wally, V.; Koller, U.; Piñón Hofbauer, J. and Guttmann-Gruber, C. (2022): Evaluating a Targeted Cancer Therapy Approach Mediated by RNA trans-Splicing In Vitro and in a Xenograft Model for Epidermolysis Bullosa-Associated Skin Cancer. International Journal of Molecular Sciences, 23 (1): 575.
Doi: https://doi.org/10.3390/ijms23010575Stierschneider, A., Grünstäudl, P., Colleselli, K., Atzler, J., Klein, C., Hundsberger, H., Wiesner, C. (2021): Light-Inducible Spatio-Temporal Control of TLR4 and NF-κB-Gluc Reporter in Human Pancreatic Cell Line. International Journal of Molecular Sciences, 22(17): 9232.
Doi: https://doi.org/10.3390/ijms22179232Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717SSun, Y., Piñón Hofbauer, J., Harada, M., Wöss, K., Koller, U., Morio, H., Stierschneider, A., Kitamura, K., Hashimoto, M., Chiba, K., Akita, H., Anzai, N., Reichelt, J., Bauer, J. W., Guttmann-Gruber, C., & Furihata, T. (2018): Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology. Cancer Letters, 433: 107-116.
Doi: https://doi.org/10.1016/j.canlet.2018.06.032Jacobi, N., Smolinska, V., Seeboeck, R., Stierschneider, A., Klein, C., Hofmann, E., Wiesner, C., Mohr, T., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2017): 3D Anti-Cancer drug discovery models: A promising approach for precision medicine. In IMC Fachhochschule Krems GmbH (Hrsg.), Online-Tagungsband FHK Forschungsforum 2017. Krems: FFH.
Jacobi, N., Smolinska, V., Stierschneider, A., Klein, C., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2016): Development of organotypic cancer models for the identification of individualized cancer therapies. In FH des BFI Wien (Hrsg.), Online-Tagungsband FHK Forschungsforum 2016. Wien: FFH.
Anna Stierschneider, PhDPhD Student Institute BiotechnologyProf.(FH) Mag. Dr. Christoph Wiesner
Professor (FH) Institute Biotechnology
Institute Biotechnology
- Cell and Molecular Biology
- Drug Screening
- Project management
- Medical and Pharmaceutical BiotechnologyBachelor of Science in Engineering / full-time
- Medical and Pharmaceutical BiotechnologyMaster of Science in Engineering / full-time
-
Optogenetische Stammzellen in heterotypische Tumorsphäroiden
Project Leader, Department of Science & Technology
-
EvoFerm
Department of Science & Technology
-
Spike-Fermentation
Department of Science & Technology
-
Entwicklung einer optogenetisch kontrollierbaren MSC-Zelllinie für die präzise Regulation immunmodulatorischer Faktoren
Project Leader, Department of Science & Technology
-
Biomarker-basierte therapeutische Prävention von Knochenmetastasen beim Mammakarzinom: die phathophysiologische Rolle der endostalen Nische
Project Leader, Department of Science & Technology
-
Entwicklung leistungsfähiger Diagnostikverfahren und neuer Therapieansätze in Inflammation und Sepsis
Project Leader, Department of Science & Technology
-
Theraferm
Department of Science & Technology
-
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Science & Technology
-
Optogenetische Krebsmodelle
Department of Science & Technology
-
Testung von rekombinanten polyklonalen Antikörperfragmenten gegen Gluten-Peptide
Department of Science & Technology
-
Zellbasierte Testsysteme für bioaktive Substanzen
Department of Science & Technology
Stierschneider, A., Wiesner, C. (2024): Shedding light on the molecular and regulatory mechanisms of TLR4 signaling in endothelial cells under physiological and inflamed conditions. Frontiers in Immunology, 14(1264889): 1-15.
Doi: https://doi.org/10.3389/fimmu.2023.1264889Colleselli, K., Stierschneider, A., Wiesner, C. (2023): An Update on Toll-like Receptor 2, Its Function and Dimerization in Pro- and Anti-Inflammatory Processes. International Journal of Molecular Sciences.
Doi: https://doi.org/10.3390/ijms241512464Colleselli, K., Ebeyer-Masotta, M., Neuditschko, B., Stierschneider, A., Pollhammer, C., Potocnjak, M., Hundsberger, H., Herzog, F., Wiesner, C. (2023): Beyond Pattern Recognition: TLR2 Promotes Chemotaxis, Cell Adhesion, and Migration in THP-1 Cells. Cells, 12(10): 1425.
Doi: https://doi.org/10.3390/cells12101425Stierschneider, A., Neuditschko, B., Colleselli, K., Hundsberger, H., Herzog, F., & Wiesner, C. (2023): Comparative and Temporal Characterization of LPS and Blue-Light-Induced TLR4 Signal Transduction and Gene Expression in Optogenetically Manipulated Endothelial Cells. Cells, 12(697).
Doi: https://doi.org/10.3390/cells12050697Weitzenböck, HP., Gschwendtner, A., Wiesner, C., Depke, M., Schmidt, F., Trautinger, F., Hengstschläger, M., Hundsberger, H., Mikula, M. (2022): Proteome analysis of NRF2 inhibition in melanoma reveals CD44 up-regulation and increased apoptosis resistance upon vemurafenib treatment. Cancer Medicine, 11(4): 956-967.
Doi: https://doi.org/10.1002/cam4.4506Stierschneider, A., Grünstäudl, P., Colleselli, K., Atzler, J., Klein, C., Hundsberger, H., Wiesner, C. (2021): Light-Inducible Spatio-Temporal Control of TLR4 and NF-κB-Gluc Reporter in Human Pancreatic Cell Line. International Journal of Molecular Sciences, 22(17): 9232.
Doi: https://doi.org/10.3390/ijms22179232Pretsch, A., Nagl, M., Wiesner, C., Hollaus, R., Genov, M. (2021): Polyguanidine polymers and methods of use thereof (US11013760B2). United States Patent Office.
Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717Sarne, V., Huter, S., Braunmueller, S., Rakob, L., Jacobi, N., Kitzwögerer, M., Wiesner, C., Obrist, P., & Seeboeck, R. (2020): Promoter Methylation of Selected Genes in Non-Small-Cell Lung Cancer Patients and Cell Lines. International journal of molecular sciences, 21(13): 4595.
Doi: https://doi.org/10.3390/ijms21134595Pretsch, A., Nagl, M., Wiesner, C., Hollaus, R., Genov, M. (2019): Method for producing polyguanidines (US10335431B2). United States Patent Office.
Jacobi, N., Seeboeck, R., Hofmann, E., Schweiger, H., Smolinska, V., Mohr, T., Boyer, A., Sommergruber, W., Lechner, P., Pichler-Huebschmann, C., Önder, K., Hundsberger, H., Wiesner, C., & Eger, A. (2017): Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signaling. Oncotarget, 8(64): 107423–107440.
Doi: https://doi.org/10.18632/oncotarget.22475Jacobi, N., Smolinska, V., Seeboeck, R., Stierschneider, A., Klein, C., Hofmann, E., Wiesner, C., Mohr, T., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2017): 3D Anti-Cancer drug discovery models: A promising approach for precision medicine. In IMC Fachhochschule Krems GmbH (Hrsg.), Online-Tagungsband FHK Forschungsforum 2017. Krems: FFH.
Hundsberger, H., Koppensteiner, A., Hofmann, E., Ripper, D., Pflüger, M., Stadlmann, V., Klein, C. T., Kreiseder, B., Katzlinger, M., Eger, A., Forster, F., Missbichler, A., & Wiesner, C. (2017): A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells. SLAS discovery : advancing life sciences R & D, 22(8): 1035–1043.
Doi: https://doi.org/10.1177/2472555217697435Pretsch, A., Nagl, M., Wiesner, C., Burgmann, H. (2017): Bioactive polymers (US9567294B2). United States Patent Office.
Genov, M., Kreiseder, B., Nagl, M., Wiesner, C. et al. (2016): Tetrahydroanthraquinone Derivative (±)-4-Deoxyaustrocortilutein Induces Cell Cycle Arrest and Apoptosis in Melanoma Cells via Upregulation of p21 and p53 and Downregulation of NF-kappaB. Journal of Cancer, 7(5): 555.
Doi: https://doi:10.7150/jca.13614Preisitsch, M., Niedermeyer, T., Heiden, SE., Neidhardt, I., Kumpfmueller, J., Wurster, M., Harmrolfs, K., Wiesner, C., Enke, H., Mueller, R., Mundt, S. (2016): Cylindrofridins A–C, Linear Cylindrocyclophane-Related Alkylresorcinols from the Cyanobacterium Cylindrospermum stagnale. Journal of natural products, 79(1): 106-115.
Doi: https://doi.org/10.1021/acs.jnatprod.5b00768Preisitsch, M., Heiden, SE., Beerbaum, M., Niedermeyer, T., Schneefeld, M., Herrmann, J., Kumpfmueller, J., Thuermer, A., Neidhardt, I., Wiesner, C., Daniel, R., Mueller, R., Bange, FC., Schmieder, P., Schweder, T., Mundt, S. (2016): Effects of halide ions on the carbamidocyclophane biosynthesis in Nostoc sp. CAVN2. Marine drugs, 14(1): 21.
Doi: https://doi.org/10.3390/md14010021Preisitsch, M., Harmrolfs, K., Pham, HT., Heidern, SE., Fuessl, A., Wiesner, C., Pretsch, A., Switecka-Hagenbruch, M., Niedermeyer, TH., Mueller, R., Mundt, S. (2015): Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2. The Journal of antibiotics, 68(9): 600-600.
Doi: https://doi.org/10.1038/ja.2015.79Kreiseder, B., Holper-Schichl, Y. M., Muellauer, B., Jacobi, N., Pretsch, A., Schmid, J. A., de Martin, R., Hundsberger, H., Eger, A., & Wiesner, C. (2015): Alpha-catulin contributes to drug-resistance of melanoma by activating NF-κB and AP-1. PloS one, 10(3): e0119402.
Doi: https://doi.org/10.1371/journal.pone.0119402Preisitsch, M., Harmrolfs, K., Pham, H., Heiden, SE., Fuessel, A., Wiesner, C., Pretsch, A., et al. (2015): Anti-MRSA-acting carbamidocyclophanes H–L from the Vietnamese cyanobacterium Nostoc sp. CAVN2. The Journal of antibiotics, 68(3): 165-177.
Doi: https://doi.org/10.1038/ja.2014.118Pretsch, A., Nagl, M., Schwendinger, K., Kreiseder, B., Wiederstein, M., Pretsch, D., Genov, M., Hollaus, R., Zinssmeister, D., Debbab, A., Hundsberger, H., Eger, A., Proksch, P., & Wiesner, C. (2014): Antimicrobial and anti-inflammatory activities of endophytic fungi Talaromyces wortmannii extracts against acne-inducing bacteria. PloS one, 9(6): e97929.
Doi: https://doi.org/10.1371/journal.pone.0097929Kreiseder, B., Orel, L., Bujnow, C., Buschek, S., Pflueger, M., Schuett, W., Hundsberger, H., de Martin, R., Wiesner, C. (2013): α‐Catulin downregulates E‐cadherin and promotes melanoma progression and invasion. International journal of cancer, 132(3): 521-530.
Doi: https://doi.org/10.1002/ijc.27698Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Onder, K., Kopecky, J., Schütt, W., Hundsberger, H. (2013): A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium. Journal of biomolecular screening, 18(1): 67-74.
Doi: https://doi.org/10.1177/1087057112458316Amatschek, S., Lucas, R., Eger, A., Pflueger, M., Hundsberger, H., Knoll, C., Grosse-Kracht, S., Schuett, W., Koszik, F., Maurer, D., Wiesner, C. (2011): CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells. British journal of cancer, 104(3): 469-479.
Doi: https://doi.org/10.1038/sj.bjc.6606056Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D., Wendel, A., Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in Bioscience, 13: 5374-86.
Doi: https://doi.org/10.2741/3087Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D. N., Wendel, A., & Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in bioscience : a journal and virtual library, 13: 5374–5386.
Doi: https://doi.org/10.2741/3087Wiesner, C., Pflueger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schuett, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene interdisziplinar, 3(1).
Wiesner, C., Pflüger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schütt, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene Interdisziplinär, 3(1): Doc05.
Wiesner, C., Winsauer, G., Resch, U. et al. (2008): α-Catulin, a Rho signalling component, can regulate NF-κB through binding to IKK-β, and confers resistance to apoptosis. Oncogene , 27: 2159–2169.
Doi: https://doi.org/10.1038/sj.onc.1210863Wiesner, C., Lucas, R., Pflueger, M., Kleber, C., Kopecky, J., Stys, D., Entler, B., Hundsberger, H., Atzler, J., Hrouzek, P., Lukesova, A., Schuett, W., (2007): Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites. Drug Metabolism Letters, 1(4): 254-260.
Doi: https://doi.org/10.2174/187231207783221385Winter, D., Moser, J., Kriehuber, E., Wiesner, C., Knobler, R., Trautinger, F., Bombosi, P., Stingl, G., Petzelbauer, P., Rot, A., & Maurer, D. (2007): Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients. Journal of immunology, 179(6): 4272-4282.
Doi: https://doi.org/10.4049/jimmunol.179.6.4272Lucas, R., Hundsberger, H., Pflueger, M., Fischer, B., Morel, D., Braun, C., Wendel, A., Chakraborty, T., Schuett, W., Wiesner, C., Hamacher, J. (2007): The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug. Letters in Drug Design & Discovery, 4(5): 336-340.
Doi: https://doi.org/10.2174%2F157018007780867816Hofer-Warbinek, R., Schmid, J.A., Mayer, H., Winsauer, G., Orel, L., Mueller, B., Wiesner, C., Binder, B.R., de Martin, R. (2004): A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. Cell Death & Differentiation, 11(12): 1317 - 1325.
Doi: https://doi.org/10.1038%2Fsj.cdd.4401502Wiesner, C., Hoeth, M., De Martin, R. (2003): Functional screening for transcription factors (US20030059858A1). United States Patent Office.
Wiesner, C., Hoeth, M., Binder, B.R., de Martin, R. (2002): A functional screening assay for the isolation of transcription factors. Nucleic Acids Research, 30(16): e80.
Doi: https://doi.org/10.1093/nar/gnf079
Prof.(FH) Mag. Dr. Christoph WiesnerProfessor (FH) Institute Biotechnology
Degree programmes and continuing education courses of the institute

Medical and Pharmaceutical Biotechnology

Medical and Pharmaceutical Biotechnology

Applied Chemistry
